Tadalafil: Uses, Dosage, Side Effects & Brands | MedexInfo

Tadalafil

Rx

Generic NameTadalafil

Therapeutic ClassPDE5 Inhibitor

Max / 24h20 mg (erectile dysfunction)

Common Dose10 mg before sexual activity; 5–20 mg as needed; 2.5–5 mg once daily (BPH or daily ED therapy)

PregnancyNot indicated in women; caution if accidental exposure

Indications ▼

Erectile dysfunction (ED) in adult men

Benign prostatic hyperplasia (BPH)

Pulmonary arterial hypertension (PAH)

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits PDE5 enzyme, increasing cGMP levels in smooth muscle cells of corpus cavernosum and pulmonary vasculature, causing relaxation and increased blood flow.

Pharmacokinetics: Rapid oral absorption; peak plasma levels in 2 hours; half-life ~17.5 hours; metabolized primarily by CYP3A4 in the liver; excreted mostly in feces and urine.

Dosage & Administration ▼

Condition	Recommended Dose	Frequency
Erectile Dysfunction	10 mg	Orally, prior to sexual activity; adjust 5–20 mg based on efficacy and tolerability
BPH	5 mg	Orally once daily
Pulmonary Arterial Hypertension	40 mg (once daily)	Orally once daily

Note: Take without regard to meals; avoid excessive alcohol; do not exceed recommended dose.

Side Effects ▼

Headache, flushing

Dyspepsia, back pain, myalgia

Nasal congestion, dizziness

Rare: Priapism, sudden hearing loss, hypotension

Contraindications ▼

Concurrent nitrate therapy (risk of severe hypotension)

Severe cardiovascular disorders (unstable angina, recent MI or stroke)

Severe hepatic or renal impairment

Hypersensitivity to tadalafil or any component

Drug Interaction ▼

Nitrates: severe hypotension

Alpha-blockers: additive blood pressure lowering effect

CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): increase tadalafil levels

CYP3A4 inducers (e.g., rifampin): decrease tadalafil efficacy

Pregnancy & Lactation ▼

Not indicated in women; safety not established

Clinical / Research Summary ▼

Therapeutic Role: First-line therapy for erectile dysfunction and approved for BPH and PAH management.

Clinical Effectiveness: Rapid onset of action; effective in improving erectile function and urinary symptoms in BPH; improves exercise capacity in PAH.

Safety Profile: Generally well tolerated; cardiovascular risk assessment recommended prior to use.

Current Research: Studies ongoing for combination therapy in PAH and long-term cardiovascular safety in ED and BPH patients.

Patient Counseling Points ▼

Take dose 30 minutes prior to sexual activity (as needed dosing)

Avoid nitrates and excessive alcohol

Report any priapism lasting >4 hours immediately

Inform physician of cardiovascular disease before use

Store at room temperature and protect from moisture and light

Storage & Handling ▼

Store at 20–25°C, protect from light and moisture

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh (Local Brands):

Adafil® Adafil 10® Celeste® Ciafil® Cialix® Ciaton® Edysta® Erectomed® Erectus® Intimate® kTx® Manlee® Megafil® Nirvana® Penfil® Prolonga® SB-Tad® Tada® Tadafil® Tadalis® Tealis® Tiagra® TopUp® Viev®

Global / International Brands:

Cialis Adcirca

Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.

Reference Hubs:

• Drug Class: PDE5 Inhibitors • Conditions: Erectile Dysfunction • Conditions: Pulmonary Arterial Hypertension