Tacrolimus Ointment: Uses, Dosage, Side Effects & Brands | MedexInfo

Tacrolimus (Topical)

Rx

Generic NameTacrolimus

Therapeutic ClassCalcineurin inhibitor

Max / 24hApply thin layer 2 times daily (do not exceed recommended area)

Common DoseApply 0.03–0.1% ointment to affected areas twice daily

PregnancyUse only if benefit outweighs risk

Indications ▼

Moderate to severe atopic dermatitis in adults and children

Inflammatory skin conditions not responding to topical corticosteroids

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits calcineurin in T-lymphocytes, reducing cytokine release and inflammation in skin lesions.

Pharmacokinetics: Minimal systemic absorption; plasma levels generally low; metabolized in the liver via CYP3A; excreted mainly in bile.

Dosage & Administration ▼

Condition	Recommended Dose	Frequency
Adults & Children ≥16 yrs (0.1% ointment)	Thin layer	Twice daily on affected areas
Children 2–15 yrs (0.03% ointment)	Thin layer	Twice daily on affected areas

Note: Avoid occlusive dressings unless directed; wash hands after application; avoid eyes and mucous membranes.

Side Effects ▼

Local burning, itching, or redness at application site

Skin infection (rare)

Transient warmth or irritation

Rare: Lymphoma or skin malignancy (long-term use caution)

Contraindications ▼

Hypersensitivity to tacrolimus or any ointment components

Viral, bacterial, or fungal skin infections at site of application

Drug Interaction ▼

Other immunosuppressants: additive immunosuppression

Topical corticosteroids: may increase skin irritation

CYP3A inhibitors/inducers (systemic absorption rare but possible)

Pregnancy & Lactation ▼

Use only if potential benefit justifies risk

Excretion in breast milk unknown; caution advised

Clinical / Research Summary ▼

Therapeutic Role: Effective non-steroidal immunomodulator for atopic dermatitis and other inflammatory skin conditions.

Clinical Effectiveness: Reduces inflammation and pruritus; suitable for sensitive areas like face and intertriginous zones.

Safety Profile: Generally well tolerated; long-term monitoring recommended for malignancy risk.

Current Research: Studies focus on comparative effectiveness vs corticosteroids, pediatric safety, and long-term outcomes.

Patient Counseling Points ▼

Apply only to affected areas; wash hands before and after application

Avoid contact with eyes, mouth, or broken skin

Report persistent redness, irritation, or infection

Limit sun exposure on treated areas

Do not use occlusive dressings unless prescribed

Storage & Handling ▼

Store at 2–8°C; protect from light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh (Local Brands):

Atolimus® 0.03% Dermus® 0.03% Prolimus® 0.03% Prolimus® 0.1% Remus® 0.03% Remus® 0.1% Rolimus® 0.03% Rolimus® 0.1% Tacroderm® 0.1% Tacrol® 0.03% Tacrol® 0.1% Tacrolim® 0.03% Tacrolim® 0.1% Vitilimus® 0.03% Vitilimus® 0.1%

Global / International Brands:

Protopic Astagraf XL

Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.

Reference Hubs:

• Drug Class: Calcineurin Inhibitors • Conditions: Atopic Dermatitis • Conditions: Inflammatory Skin Disorders