Propantheline Bromide: Uses,Dosage,Side Effects| MedexInfo

Propantheline Bromide

Rx Only

Generic NamePropantheline Bromide

Therapeutic ClassAnticholinergic / Gastrointestinal Antispasmodic

Common Dose15–30 mg orally 3–4 times daily

Max / 24h120 mg

PregnancyCategory C

Indications ▼

Peptic ulcer disease – to reduce gastric acid secretion and relieve spasms

Irritable bowel syndrome with predominant spasmodic symptoms

Hyperhidrosis (off-label)

Control of excessive salivation in some conditions

Mechanism & Pharmacokinetics ▼

Mechanism: Competitively blocks muscarinic receptors, reducing parasympathetic activity, smooth muscle spasms, and secretions in the GI tract and other tissues.

Pharmacokinetics: Absorbed orally; metabolized in the liver; excreted in urine; half-life ~2–4 hours; minimal CNS penetration.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	15–30 mg orally 3–4 times daily before meals and at bedtime	120 mg
Elderly	Start at lower end; monitor for anticholinergic side effects	90 mg
Children ≥12 years	5–10 mg orally 3–4 times daily	40 mg

Note: Administer 30 minutes before meals for optimal effect. Adjust dose in renal or hepatic impairment.

Side Effects ▼

Dry mouth, blurred vision, constipation, urinary retention

Headache, dizziness, drowsiness

Tachycardia, palpitations (rare)

Contraindications ▼

Narrow-angle glaucoma

Myasthenia gravis

Severe ulcerative colitis or intestinal obstruction

Hypersensitivity to propantheline or anticholinergics

Drug Interaction ▼

Other anticholinergic drugs may increase side effects

May reduce efficacy of drugs requiring parasympathetic activity (e.g., bethanechol)

Concurrent antihistamines or tricyclic antidepressants increase anticholinergic burden

Pregnancy & Lactation ▼

Use only if benefits outweigh risks; limited human data

Excreted in breast milk in small amounts; monitor infant for anticholinergic effects

Clinical / Research Summary ▼

Effective in controlling GI smooth muscle spasms and reducing secretions

Used in peptic ulcer disease as adjunct therapy

Backed by clinical studies and expert recommendations

Patient Counseling Points ▼

Take exactly as prescribed; do not exceed recommended dose

Avoid driving or operating machinery until alertness is confirmed

Report severe dry mouth, constipation, urinary retention, or palpitations

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Thelin® 15 mg Prokind® 15 mg Propa® 15 mg

Global:

Pro-Banthine® Propantheline Bromide

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Anticholinergics / GI Antispasmodics • Condition: Peptic Ulcer & GI Spasms • Pathway: Muscarinic Receptor Blockade • Clinical Evidence & Trials