Trimetazidine Dihydrochloride: Uses, Dosage, Side Effects | MedexInfo

Trimetazidine Dihydrochloride

Rx

Generic NameTrimetazidine Dihydrochloride

Therapeutic ClassMetabolic Antianginal Agent

Common Strength20 mg, 35 mg tablet

Max / 24h70 mg

PregnancyUse if benefit outweighs risk

Indications ▼

Stable angina pectoris (as adjunct to standard therapy)

Ischemic heart disease with limited exercise tolerance

Vertigo, tinnitus, or visual disturbances associated with ischemia

Mechanism & Pharmacokinetics ▼

Mechanism: Trimetazidine improves myocardial glucose utilization by inhibiting fatty acid oxidation, thus maintaining energy production under ischemic conditions. It has a cytoprotective effect on myocardial cells.

Pharmacokinetics: Well absorbed orally. Peak plasma concentration in 1–2 hours. Minimal metabolism. Excreted mainly via urine. Half-life ~6 hours.

Dosage & Administration ▼

Indication	Dose	Frequency
Adults (Stable Angina)	20 mg	3 times daily or 35 mg twice daily
Elderly / renal impairment	Adjust dose	As directed by physician

Note: Continue standard antianginal therapy; trimetazidine is adjunctive.

Side Effects ▼

Nausea, vomiting

Abdominal discomfort

Headache, dizziness

Rare: Parkinsonism, tremor, restlessness

Skin rash or allergic reaction (rare)

Contraindications ▼

Hypersensitivity to trimetazidine

Parkinson’s disease or movement disorders

Severe renal impairment (dose adjustment required)

Drug Interaction ▼

Other antianginal agents: generally safe as adjunct

Drugs affecting CNS dopamine: caution in Parkinson’s disease

Pregnancy & Lactation ▼

Limited data in humans; use only if clearly indicated

Caution advised during breastfeeding

Clinical / Research Summary ▼

Clinical Role: Adjunct metabolic therapy for angina; protects myocardium under ischemic conditions.

Advantage: Improves exercise tolerance and reduces angina attacks.

Limitation: Not a first-line antianginal; cannot replace standard therapy.

Monitoring: Symptom improvement, movement disorders in long-term use.

Patient Counseling Points ▼

Take with meals to reduce GI discomfort

Report tremors, restlessness, or abnormal movements

Continue other prescribed antianginal medications

Storage & Handling ▼

Store below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Angivent MR® 35 mg Vastarel MR® 35 mg Angimet® 20 mg Angimet MR® 35 mg Anginox MR® 35 mg Angirid MR® 35 mg Angitrim MR® 35 mg Angivas MR® 35 mg Antoris MR® 35 mg Cardimet MR® 35 mg Feelnor MR® 35 mg Metacard MR® 35 mg Metazine MR® 35 mg Trangit MR® 35 mg Triginal MR® 35 mg Trizedon MR® 35 mg Trimet MR® 35 mg Trimet® 20 mg Vascare® 20 mg

Global:

Vastarel MR®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Metabolic Antianginals • Condition: Stable Angina