Trimebutine Maleate: Uses, Dosage, Side Effects & Brands | MedexInfo

Trimebutine Maleate

Rx

Generic NameTrimebutine Maleate

Therapeutic ClassGastrointestinal Motility Modulator

Common Strength100 mg tablet; 200 mg tablet; 100 mg/5 mL suspension

Max / 24h600 mg

PregnancyUse if benefit outweighs risk

Indications ▼

Irritable Bowel Syndrome (IBS) with abdominal pain or discomfort

Functional gastrointestinal disorders with spasms

Postoperative gastrointestinal motility disturbances

Mechanism & Pharmacokinetics ▼

Mechanism: Trimebutine is a spasmolytic agent that modulates gastrointestinal motility via peripheral opioid receptors (μ, κ, δ) and has a mild effect on the enteric nervous system. It normalizes both hyper- and hypo-motility.

Pharmacokinetics: Rapidly absorbed orally. Undergoes hepatic metabolism. Elimination half-life is approximately 2 hours. Excreted mainly via urine.

Dosage & Administration ▼

Indication	Dose	Frequency
Adults (IBS, GI spasm)	100–200 mg	3 times daily before meals
Children (as suspension)	5–10 mg/kg	3 times daily

Note: Adjust dose based on response. Do not exceed 600 mg/day in adults.

Side Effects ▼

Nausea, vomiting

Abdominal discomfort

Dizziness, headache

Rash or allergic reaction (rare)

Constipation or diarrhea (less common)

Contraindications ▼

Hypersensitivity to trimebutine

Severe hepatic impairment

Severe renal impairment

Drug Interaction ▼

Other antispasmodics: additive effect

Opioid agonists: possible additive GI motility modulation

Pregnancy & Lactation ▼

Limited data; use only if clinically necessary

Excreted in breast milk in small amounts; caution advised

Clinical / Research Summary ▼

Clinical Role: Modulates gastrointestinal motility and reduces abdominal pain/spasm in functional disorders.

Advantage: Effective in both hyper- and hypo-motility conditions.

Limitation: Symptomatic relief only; does not cure underlying disease.

Monitoring: Symptom control, liver/renal function in prolonged use.

Patient Counseling Points ▼

Take before meals for optimal effect

Report persistent abdominal pain or allergic reaction

Do not exceed recommended dose

Storage & Handling ▼

Store below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Timotor® 100 mg Trimotil® 100 mg Tritin® 100 mg

Global:

Debridat®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Gastrointestinal Motility Modulators • Condition: Irritable Bowel Syndrome