Tranexamic Acid: Uses, Dosage, Side Effects & Brands | MedexInfo

Tranexamic Acid

Rx

Generic NameTranexamic Acid

Therapeutic ClassAntifibrinolytic Agent

Common Strength250 mg, 500 mg (tablet); 500 mg/5 mL (injection)

Max / 24h4 g (oral)

PregnancyUse if benefit outweighs risk

Indications ▼

Heavy menstrual bleeding (menorrhagia)

Prevention and treatment of surgical bleeding

Trauma-related hemorrhage

Bleeding disorders with hyperfibrinolysis

Hereditary angioedema (prophylaxis)

Mechanism & Pharmacokinetics ▼

Mechanism: Tranexamic acid is a synthetic lysine analogue that inhibits fibrinolysis by reversibly blocking lysine-binding sites on plasminogen, preventing its conversion to plasmin and stabilizing formed clots.

Pharmacokinetics: Well absorbed orally. Minimal metabolism. Eliminated primarily unchanged via renal excretion. Plasma half-life is approximately 2–3 hours.

Dosage & Administration ▼

Indication	Dose	Frequency
Menorrhagia	1–1.5 g	2–3 times daily for up to 5 days
Postoperative / Trauma bleeding	500 mg–1 g (IV)	Every 6–8 hours as needed
Hereditary angioedema	1–1.5 g	2–3 times daily

Note: Dose adjustment required in renal impairment.

Side Effects ▼

Nausea, vomiting, diarrhea

Abdominal discomfort

Dizziness, headache

Visual disturbances (rare)

Rare: thromboembolic events, seizures (high-dose IV)

Contraindications ▼

Active intravascular clotting

History of thromboembolic disease

Severe renal impairment (without dose adjustment)

Subarachnoid hemorrhage

Hypersensitivity to tranexamic acid

Drug Interaction ▼

Hormonal contraceptives: increased risk of thrombosis

Other procoagulant agents: additive thrombotic risk

Thrombolytics: antagonized effect

Pregnancy & Lactation ▼

Can be used if clinically indicated

No strong evidence of teratogenicity

Excreted in breast milk in small amounts; generally considered safe

Clinical / Research Summary ▼

Clinical Role: Key antifibrinolytic used to reduce bleeding without affecting coagulation.

Evidence: Proven mortality benefit in trauma and postpartum hemorrhage when used early.

Limitation: Thrombotic risk in predisposed patients.

Monitoring: Renal function, visual symptoms, thrombotic signs.

Patient Counseling Points ▼

Take exactly as prescribed

Report visual changes or leg swelling immediately

Do not exceed recommended duration for menstrual bleeding

Inform doctor if using hormonal contraceptives

Storage & Handling ▼

Store below 30°C

Protect from light and moisture

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Anaxyl® 500 mg Anaxyl® 500 mg/5 ml Inj Bionex® 500 mg Block-T® 500 mg Block-T® 500 mg/5 ml Inj Enclot® 250 mg Enclot® 500 mg Enclot® 500 mg/5 ml Inj Fibrino® 500 mg Fibrino® 500 mg/5 ml Inj Fibrostat® 500 mg/5 ml Inj Frabex® 500 mg Hemostop® 500 mg Hemotrax® 500 mg Hemotrax® 500 mg/5 ml Inj Intrax® 500 mg Intrax® 500 mg/5 ml Inj Nexyl® 500 mg Oranex® 500 mg Taxiclot® 500 mg Texamic® 500 mg Tracid® 500 mg Tracid® 500 mg/5 ml Inj Tranexil® 500 mg Tranexil® 500 mg/5 ml Inj Trapic® 500 mg Traxyl® 500 mg Traxyl® 500 mg/5 ml Inj Trexam® 500 mg Xamic® 500 mg Xamic® 500 mg/5 ml Inj Global:

Cyklokapron®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Antifibrinolytics • Condition: Bleeding Disorders

Tranexamic Acid: Uses, Dosage, Side Effects & Brands | MedexInfo Reviewed by Rasel Bapy on 04 May Rating: 5