Tolterodine Tartrate: Uses, Dosage, Side Effects & Brands | MedexInfo

Tolterodine Tartrate

Rx

Generic NameTolterodine Tartrate

Therapeutic ClassAntimuscarinic (Bladder Relaxant)

Dosage FormTablet (IR & ER)

Common Dose2 mg IR twice daily / 4 mg ER once daily

PregnancyUse only if clearly necessary

Indications ▼

Overactive bladder with urinary urgency

Urinary frequency

Urge urinary incontinence

Mechanism & Pharmacokinetics ▼

Mechanism: Competitive muscarinic receptor antagonist. Reduces involuntary detrusor muscle contractions by inhibiting acetylcholine effects in the bladder.

Absorption: Well absorbed orally. Food has minimal effect.

Metabolism: Hepatic via CYP2D6 and CYP3A4 to active metabolite 5-hydroxymethyl tolterodine.

Elimination: Renal and fecal. Half-life ~2–4 hours (longer in poor metabolizers).

Dosage & Administration ▼

Immediate-release (IR): 2 mg orally twice daily

Extended-release (ER): 4 mg orally once daily

Take with or without food

Dose adjustment needed in hepatic impairment, severe renal impairment, or when used with potent CYP3A4 inhibitors: 1 mg IR twice daily or 2 mg ER once daily

Side Effects ▼

Dry mouth (most common)

Constipation

Headache

Dizziness

Blurred vision

Urinary retention (rare)

Allergic reactions (rare)

Contraindications ▼

Urinary retention

Gastric retention

Uncontrolled narrow-angle glaucoma

Hypersensitivity to tolterodine

Drug Interaction ▼

Potent CYP3A4 inhibitors (ketoconazole, clarithromycin) increase plasma levels

Other antimuscarinics: additive anticholinergic effects (dry mouth, constipation, blurred vision)

Use caution with CNS depressants due to increased dizziness risk

Pregnancy & Lactation ▼

Pregnancy: Use only if clearly necessary; limited human data

Lactation: Not recommended; unknown if excreted in breast milk

Clinical / Research Summary ▼

Clinical Role: First-line antimuscarinic therapy for overactive bladder and urge incontinence.

Advantage: Improves urinary urgency, frequency, and incontinence episodes.

Limitation: Anticholinergic side effects may limit use in elderly patients.

Monitoring: Symptom response, side effects (dry mouth, constipation, urinary retention), renal and hepatic function in impaired patients.

Patient Counseling Points ▼

Take consistently at the same times each day

May cause dry mouth and constipation; maintain hydration

Avoid driving if dizziness or blurred vision occurs

Report urinary retention or severe side effects immediately

Storage & Handling ▼

Store below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Global:

Detrol® Detrol LA®

Bangladesh:

Detrusin LA® 2 mg ER Detrusin LA® 4 mg ER Tolorin® 2 mg Tolter® 1 mg Tolter® 2 mg Toltrex® 2 mg Ucol® 2 mg Uritol® 1 mg Uritol® 2 mg

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Antimuscarinics • Condition: Overactive Bladder • Condition: Urinary Incontinence