Tolperisone + Lidocaine: Uses, Dosage, Side Effects | MedexInfo

Tolperisone + Lidocaine

Rx

Generic NameTolperisone Hydrochloride + Lidocaine

Therapeutic ClassMuscle Relaxant + Local Anesthetic

Dosage FormInjection (IM)

Common Dose100 mg Tolperisone + 2.5 mg Lidocaine

PregnancyAvoid

Indications ▼

Acute painful muscle spasm

Spasticity following stroke

Spinal cord and neurological spasticity

Painful musculoskeletal disorders requiring injection therapy

Mechanism & Pharmacokinetics ▼

Mechanism: Tolperisone reduces muscle tone by inhibiting spinal reflex pathways without significant sedation. Lidocaine provides local anesthetic action at the injection site, reducing injection-related pain.

Pharmacokinetics: Tolperisone is rapidly absorbed after IM injection and extensively metabolized in liver and kidneys. Lidocaine has rapid local onset with limited systemic exposure at therapeutic doses.

Dosage & Administration ▼

Indication	Dose	Frequency
Muscle spasm / Spasticity	1 ampoule (100 mg + Lidocaine)	IM once daily

Note: Switch to oral tolperisone once acute symptoms improve.

Side Effects ▼

Dizziness, headache

Muscle weakness

Injection site pain or irritation

Nausea, hypotension (rare)

Allergic reactions (rare but serious)

Contraindications ▼

Hypersensitivity to tolperisone or lidocaine

Myasthenia gravis

Severe hypotension or cardiac conduction disorders

Pregnancy and breastfeeding

Drug Interaction ▼

Other muscle relaxants: additive muscle weakness

CNS depressants: increased dizziness

Class I antiarrhythmics: increased cardiac risk with lidocaine

Pregnancy & Lactation ▼

Avoid use during pregnancy unless clearly necessary

Not recommended during breastfeeding

Clinical / Research Summary ▼

Clinical Role: Short-term injectable therapy for acute painful spasticity.

Advantage: Rapid symptom relief with reduced injection discomfort.

Limitation: Not suitable for long-term use.

Monitoring: Blood pressure and allergic reactions.

Patient Counseling Points ▼

Injection should be given by a healthcare professional

Report dizziness or rash immediately

Avoid driving if dizziness occurs

Follow-up for switch to oral therapy

Storage & Handling ▼

Store below 30°C

Protect from light

Do not freeze

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Myolax Plus® (100 mg + 2.5 mg)

Global:

Mydocalm Injection

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Muscle Relaxants • Condition: Muscle Spasm • Condition: Spasticity