Tolperisone Hydrochloride: Uses, Dosage, Side Effects | MedexInfo

Tolperisone Hydrochloride

Rx

Generic NameTolperisone Hydrochloride

Therapeutic ClassCentrally Acting Muscle Relaxant

Common Dose150–450 mg/day

Max / 24h450 mg

PregnancyAvoid

Indications ▼

Acute muscle spasm associated with musculoskeletal disorders

Spasticity following stroke

Spasticity in multiple sclerosis and spinal cord disorders

Painful muscle rigidity and cramps

Mechanism & Pharmacokinetics ▼

Mechanism: Tolperisone acts centrally by stabilizing neuronal membranes and inhibiting monosynaptic and polysynaptic reflex transmission in the spinal cord. It reduces muscle tone without significant sedation.

Pharmacokinetics: Rapid oral absorption. Extensive first-pass metabolism. Peak plasma levels within 1 hour. Metabolized in liver and kidneys. Excreted mainly in urine.

Dosage & Administration ▼

Indication	Dose	Frequency
Muscle spasm (oral)	150–450 mg	In 3 divided doses after meals
Injection	100 mg	IM once daily or IV twice daily

Note: Start with lower doses and titrate according to response.

Side Effects ▼

Dizziness, headache

Muscle weakness

Nausea, abdominal discomfort

Hypotension (rare)

Hypersensitivity reactions (rash, pruritus)

Contraindications ▼

Known hypersensitivity to Tolperisone

Myasthenia gravis

Severe hypotension

Pregnancy and breastfeeding (unless clearly necessary)

Drug Interaction ▼

Other muscle relaxants: additive effects

CNS depressants: increased dizziness

NSAIDs: may increase tolperisone plasma levels

Pregnancy & Lactation ▼

Avoid use during pregnancy unless benefit outweighs risk

Not recommended during breastfeeding

Clinical / Research Summary ▼

Clinical Role: Effective muscle relaxant with minimal sedative effect.

Advantage: Suitable for patients who need to remain alert.

Limitation: Limited data in pregnancy.

Monitoring: Blood pressure and signs of hypersensitivity.

Patient Counseling Points ▼

Take after meals to improve tolerability

Do not exceed prescribed dose

Report dizziness or allergic reactions promptly

Avoid driving if dizziness occurs

Storage & Handling ▼

Store below 30°C

Protect from light and moisture

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Tolson® 50 mg Tolson® 100 mg Tolmus® 50 mg Tolcalm® 50 mg Toperin® 50 mg A-Calm® 50 mg Lexaton® 50 mg Musclex® 50 mg Myolax® 50 mg Myolax® 100 mg Myoson® 50 mg Myoson® 100 mg Myotol® 50 mg Myoxan® 50 mg Myoxant® 50 mg Rison® 50 mg Tolpa® 50 mg Tolride® 50 mg Tolus® 50 mg

Global:

Mydocalm

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Muscle Relaxants • Condition: Muscle Spasm • Condition: Spasticity