Pyridoxine Hydrochloride + Doxylamine Succinate: Uses, Dosage | MedexInfo

Pyridoxine Hydrochloride + Doxylamine Succinate

Rx Only

Generic NamePyridoxine HCl + Doxylamine Succinate

Therapeutic ClassAntiemetic / Antihistamine Combination

Common Dose2 tablets at bedtime; may increase as needed

Max / 24h4 tablets

PregnancyCategory A

Indications ▼

Nausea and vomiting of pregnancy (NVP)

Hyperemesis gravidarum (as part of management)

Mechanism & Pharmacokinetics ▼

Mechanism: Pyridoxine (Vitamin B6) modulates neurotransmitter synthesis; Doxylamine blocks H1 histamine receptors, reducing nausea signals in the brain.

Pharmacokinetics: Well absorbed orally; doxylamine undergoes hepatic metabolism; pyridoxine converted to active form (PLP); excreted via urine; prolonged action with delayed-release formulation.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults (Pregnant Women)	Start with 2 tablets at bedtime; may add 1 tablet in morning and afternoon if needed	4 tablets
Elderly	Not typically indicated	—
Children	Not recommended	—

Note: Take on an empty stomach with a glass of water. Swallow tablets whole; do not crush or chew.

Side Effects ▼

Drowsiness, dizziness

Dry mouth, constipation

Fatigue, headache

Contraindications ▼

Hypersensitivity to doxylamine, pyridoxine, or antihistamines

Concurrent use with MAO inhibitors

Angle-closure glaucoma or severe urinary retention

Drug Interaction ▼

Other CNS depressants (alcohol, sedatives) increase drowsiness

MAO inhibitors may prolong and intensify effects

Anticholinergic drugs may increase side effects

Pregnancy & Lactation ▼

Category A: safe and widely used for nausea and vomiting in pregnancy

Doxylamine may pass into breast milk; caution advised during breastfeeding

Clinical / Research Summary ▼

First-line therapy for nausea and vomiting of pregnancy

Demonstrated safety and efficacy in multiple clinical trials

Recommended in international obstetric guidelines

Patient Counseling Points ▼

May cause drowsiness; avoid driving or operating machinery

Take regularly as prescribed, not on an as-needed basis

Avoid alcohol and other sedatives

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Doxinate®

Global:

Diclegis® / Bonjesta® Pyridoxine + Doxylamine

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Antiemetics • Condition: Nausea & Vomiting in Pregnancy • Pathway: H1 Receptor Blockade • Clinical Evidence & Trials