Olanzapine: Uses, Dosage, Side Effects & Brands | MedexInfo

Olanzapine

Rx Only

Generic NameOlanzapine

Therapeutic ClassAtypical Antipsychotic

Common Dose5–20 mg daily

Max / 24h20 mg

PregnancyCategory C

Indications ▼

Schizophrenia

Bipolar disorder (acute mania and maintenance)

Agitation associated with psychosis

Adjunct in treatment-resistant depression (with antidepressants)

Mechanism & Pharmacokinetics ▼

Mechanism: Antagonizes dopamine (D2) and serotonin (5-HT2A) receptors, improving psychotic symptoms and mood stabilization.

Pharmacokinetics: Well absorbed orally; extensive hepatic metabolism (CYP1A2, CYP2D6); half-life ~21–54 hours; excreted via urine and feces.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	Start 5–10 mg daily; titrate up to 20 mg/day	20 mg
Elderly	Start 2.5–5 mg daily; adjust cautiously	20 mg
Children ≥13 years	2.5–5 mg daily; titrate per response	20 mg

Note: Can be taken with or without food. Gradual dose adjustment recommended.

Side Effects ▼

Weight gain, increased appetite

Sedation, dizziness

Hyperglycemia, dyslipidemia

Extrapyramidal symptoms (less common)

Contraindications ▼

Hypersensitivity to olanzapine

Caution in patients with diabetes, cardiovascular disease

History of neuroleptic malignant syndrome

Drug Interaction ▼

CNS depressants increase sedation

CYP1A2 inducers (e.g., smoking) may reduce plasma levels

CYP inhibitors may increase drug concentration

Pregnancy & Lactation ▼

Use only if benefits outweigh risks

Excreted in breast milk; monitor infant for sedation

Clinical / Research Summary ▼

Effective atypical antipsychotic for schizophrenia and bipolar disorder

Lower EPS risk compared to typical antipsychotics

Metabolic monitoring required due to weight and glucose effects

Patient Counseling Points ▼

Take regularly as prescribed

Monitor weight, blood sugar, and lipid levels

Avoid alcohol; may cause drowsiness

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Olanzapine Tablets

Global:

Zyprexa® Olanzapine

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Atypical Antipsychotics • Condition: Schizophrenia & Bipolar Disorder • Pathway: Dopamine & Serotonin Modulation • Clinical Evidence & Trials