Pseudoephedrine + Guaiphenesin + Triprolidine | MedexInfo
Pseudoephedrine + Guaiphenesin + Triprolidine
OTC / Rx
Generic NamePseudoephedrine + Guaiphenesin + Triprolidine
Therapeutic ClassDecongestant + Expectorant + Antihistamine
Common Dose1 tablet every 6–8 hours
Max / 24hAs per formulation strength
PregnancyCategory C
Indications ▼
Symptomatic relief of common cold and upper respiratory tract infections
Nasal congestion, sinus congestion
Productive cough with mucus
Allergic symptoms (sneezing, runny nose)
Mechanism & Pharmacokinetics ▼
Mechanism: Pseudoephedrine acts as a sympathomimetic causing vasoconstriction to reduce nasal congestion; Guaiphenesin increases respiratory tract fluid to thin mucus; Triprolidine blocks H1 receptors to reduce allergic symptoms.
Pharmacokinetics: Well absorbed orally; pseudoephedrine excreted largely unchanged in urine; guaiphenesin metabolized and excreted renally; triprolidine undergoes hepatic metabolism; duration varies by component.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults | 1 tablet every 6–8 hours as needed | Follow label instructions |
| Elderly | Start at lower dose; monitor for CNS and cardiovascular effects | As per clinician |
| Children ≥6 years | Use pediatric formulation as per weight/age | Follow pediatric guidelines |
Note: Take with adequate fluids. Avoid taking close to bedtime due to stimulant effect.
Side Effects ▼
Drowsiness or sedation (triprolidine)
Insomnia, nervousness, palpitations (pseudoephedrine)
Nausea, gastrointestinal discomfort
Dry mouth, dizziness
Contraindications ▼
Severe hypertension or coronary artery disease
Concurrent MAO inhibitor use
Hypersensitivity to any component
Angle-closure glaucoma or urinary retention
Drug Interaction ▼
MAO inhibitors may cause hypertensive crisis
Other CNS depressants increase sedation
Antihypertensives may have reduced effect
Pregnancy & Lactation ▼
Use only if benefits outweigh risks; avoid in first trimester if possible
May pass into breast milk; caution advised during breastfeeding
Clinical / Research Summary ▼
Provides multi-symptom relief in cold and allergy conditions
Combines decongestant, expectorant, and antihistamine actions
Widely used in OTC cold preparations
Patient Counseling Points ▼
Avoid alcohol and sedatives due to drowsiness risk
Do not exceed recommended dose
Report palpitations, severe dizziness, or allergic reactions
Storage & Handling ▼
Store at 20–25°C (68–77°F)
Protect from moisture and light
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.
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