Protamine Crystallised Insulin Aspart: Uses, Dosage, Side Effects | MedexInfo

Protamine Crystallised Insulin Aspart

Rx Only

Generic NameInsulin Aspart Protamine + Insulin Aspart

Therapeutic ClassAntidiabetic / Biphasic Insulin Analog

Common DoseIndividualized; commonly 0.5–1 unit/kg/day in divided doses

Max / 24hIndividualized based on glycemic response

PregnancyCategory B

Indications ▼

Type 1 diabetes mellitus (as part of insulin regimen)

Type 2 diabetes mellitus requiring insulin therapy

Control of both postprandial and basal blood glucose levels

Mechanism & Pharmacokinetics ▼

Mechanism: Combination of rapid-acting insulin aspart and intermediate-acting protamine-bound insulin aspart; facilitates glucose uptake into cells and inhibits hepatic glucose production.

Pharmacokinetics: Rapid onset (10–20 minutes), peak effect from rapid component within 1–3 hours and prolonged action up to 24 hours from protamine component; administered subcutaneously.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	Individualized; typically 0.5–1 unit/kg/day in 1–2 divided doses before meals	Based on glycemic control
Elderly	Start conservatively; adjust based on glucose monitoring	Individualized
Children	Dose individualized per weight and glucose levels	Individualized

Note: Administer subcutaneously before meals. Rotate injection sites. Do not administer intravenously.

Side Effects ▼

Hypoglycemia (most common)

Weight gain

Injection site reactions (lipodystrophy, redness)

Rare: hypersensitivity reactions

Contraindications ▼

Hypoglycemia episodes

Hypersensitivity to insulin aspart or any component

Drug Interaction ▼

Oral antidiabetics may enhance hypoglycemic effect

Corticosteroids, thiazides may increase blood glucose levels

Beta-blockers may mask hypoglycemia symptoms

Pregnancy & Lactation ▼

Generally safe in pregnancy; preferred insulin therapy when needed

Safe in breastfeeding; insulin does not pass significantly into breast milk

Clinical / Research Summary ▼

Provides both basal and prandial glucose control in a single formulation

Improves glycemic control with fewer injections compared to basal-bolus regimens

Supported by clinical trials in both type 1 and type 2 diabetes

Patient Counseling Points ▼

Monitor blood glucose regularly

Recognize and manage symptoms of hypoglycemia

Rotate injection sites to avoid lipodystrophy

Storage & Handling ▼

Store unopened vials/pens in refrigerator (2–8°C)

Do not freeze; protect from light

Once opened, may be kept at room temperature for limited duration (per manufacturer)

Brand Names (Bangladesh & Global) ▼

Bangladesh:

NovoMix® 30

Global:

NovoMix® 30 / NovoLog® Mix 70/30 Biphasic Insulin Aspart

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Insulin Analogs • Condition: Diabetes Mellitus • Pathway: Insulin Receptor Signaling • Clinical Evidence & Trials