Prednisolone: Uses, Dosage, Side Effects & Brands | MedexInfo

Prednisolone

Rx Only

Generic NamePrednisolone

Therapeutic ClassCorticosteroid

Common Dose5–60 mg daily depending on condition

Max / 24h100 mg

PregnancyCategory C

Indications ▼

Inflammatory and autoimmune conditions (e.g., rheumatoid arthritis, lupus)

Severe allergies and asthma exacerbations

Adrenal insufficiency

Certain hematologic and oncologic conditions

Shock or severe systemic inflammation

Mechanism & Pharmacokinetics ▼

Mechanism: Binds to glucocorticoid receptors, modulating gene transcription to suppress inflammation and immune response.

Pharmacokinetics: Well absorbed orally; metabolized in liver; excreted primarily via urine; half-life ~3–4 hours; biological effects longer due to receptor binding.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	5–60 mg orally daily, dose individualized per condition	100 mg
Elderly	Start at lower end; monitor for side effects	100 mg
Children	0.14–2 mg/kg/day orally in divided doses	Depends on indication

Note: Taper gradually after long-term use to avoid adrenal insufficiency. Can be given with food to reduce GI irritation.

Side Effects ▼

Hyperglycemia, fluid retention, weight gain

Increased infection risk, mood changes, insomnia

Osteoporosis, adrenal suppression with long-term use

Gastrointestinal irritation or ulceration

Contraindications ▼

Systemic fungal infections

Hypersensitivity to prednisolone or other corticosteroids

Caution in uncontrolled infections, diabetes, hypertension, peptic ulcer

Drug Interaction ▼

Concurrent NSAIDs increase risk of GI ulceration

May reduce efficacy of vaccines

CYP3A4 inhibitors/inducers can alter plasma levels

Diuretics may worsen hypokalemia risk

Pregnancy & Lactation ▼

Use only if benefits outweigh risks; potential for fetal growth restriction

Excreted in breast milk in small amounts; monitor infant for adrenal effects

Clinical / Research Summary ▼

Effective anti-inflammatory and immunosuppressive agent in a wide range of conditions

Rapid symptom relief in acute exacerbations of asthma and autoimmune diseases

Well-studied in numerous clinical trials and guidelines

Patient Counseling Points ▼

Take exactly as prescribed; do not stop abruptly after long-term use

Take with food to minimize GI upset

Report signs of infection, unusual bruising, or hyperglycemia

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Adam® 5 mg Tablet Adam® 20 mg Tablet Cortan® 2 mg Tablet Cortan® 5 mg Tablet Cortan® 10 mg Tablet Cortan® 20 mg Tablet Cortisol® 5 mg Tablet Cortisol® 10 mg Tablet G‑Prednisolone® 5 mg Tablet Inflagic® 20 mg Tablet P‑Cort® 5 mg Tablet Pred® 5 mg Tablet Pred® 10 mg Tablet Pred® 20 mg Tablet Predimax® 5 mg Tablet Predimax® 10 mg Tablet Predimax® 20 mg Tablet Pednisol® 5 mg Tablet Pednisol® 10 mg Tablet Pednisol® 20 mg Tablet Deltasone® 5 mg Tablet Deltasone® 10 mg Tablet Deltasone® 20 mg Tablet Pednil® 5 mg Tablet Pednil® 10 mg Tablet Kidpred® 5 mg/5 ml Oral Solution Pedipred® 5 mg/5 ml Oral Solution P‑Cort® 5 mg/5 ml Oral Solution

Global:

Prednisolone® Prednisolone

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Corticosteroids • Condition: Inflammatory & Autoimmune Diseases • Pathway: Glucocorticoid Receptor Modulation • Clinical Evidence & Trials