Prasugrel Hydrochloride: Uses, Dosage, Side Effects | MedexInfo

Prasugrel Hydrochloride

Rx Only

Generic NamePrasugrel Hydrochloride

Therapeutic ClassAntiplatelet Agent, Thienopyridine

Common Dose10 mg once daily

Max / 24h10 mg

PregnancyNot Classified

Indications ▼

Prevention of thrombotic cardiovascular events in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI)

Reduce risk of heart attack or stroke in high-risk patients

Mechanism & Pharmacokinetics ▼

Mechanism: Irreversibly inhibits platelet P2Y12 ADP receptors, reducing platelet aggregation.

Pharmacokinetics: Rapidly absorbed orally; converted to active metabolite by hepatic esterases; peak plasma levels ~30 min; half-life ~7 hours; excreted via urine and feces.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	10 mg orally once daily	10 mg
Elderly ≥75 years	Use only if high-risk ACS; consider 5 mg	10 mg
Patients <60 kg	Consider 5 mg daily	10 mg

Note: Administer with or without food. Do not discontinue without physician guidance.

Side Effects ▼

Bleeding (major or minor)

Bruising, nosebleed, gastrointestinal hemorrhage

Rare: Thrombocytopenia, hypersensitivity reactions

Contraindications ▼

Active pathological bleeding

History of stroke or transient ischemic attack (TIA)

Hypersensitivity to prasugrel

Drug Interaction ▼

Concurrent anticoagulants increase bleeding risk

NSAIDs may increase gastrointestinal bleeding

CYP3A and CYP2B6 inhibitors/inducers may alter metabolism

Pregnancy & Lactation ▼

Safety not established in pregnancy

Use only if benefits outweigh risks; monitor bleeding in neonates if breastfeeding

Clinical / Research Summary ▼

Reduces risk of cardiovascular events in ACS patients undergoing PCI

Rapid onset of platelet inhibition compared to clopidogrel

Well-studied in TRITON-TIMI 38 trial

Patient Counseling Points ▼

Take exactly as prescribed; do not skip doses

Report any unusual bleeding or bruising

Avoid NSAIDs or other antiplatelets unless advised

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Apagrel® 5 mg Apagrel® 10 mg Appras® 5 mg Appras® 10 mg Efirel® 5 mg Efirel® 10 mg Prapid® 5 mg Prapid® 10 mg Prasulet® 5 mg Prasulet® 10 mg Prasurel® 5 mg Prasurel® 10 mg Prasuva® 5 mg Prasuva® 10 mg

Global:

Efient® Prasugrel Hydrochloride

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Antiplatelets • Condition: Acute Coronary Syndrome • Pathway: Platelet Inhibition • Clinical Evidence & Trials