Pramoxine Hydrochloride + Calamine: Uses, Dosage | MedexInfo

Pramoxine Hydrochloride + Calamine

OTC

Generic NamePramoxine Hydrochloride + Calamine

Therapeutic ClassTopical Antipruritic / Skin Protectant

Common StrengthPramoxine 1% + Calamine 8%

RouteTopical

PregnancyGenerally considered safe (topical)

Indications ▼

Itching due to minor skin irritation

Insect bites and stings

Allergic rashes

Sunburn and mild burns

Contact dermatitis

Mechanism & Pharmacokinetics ▼

Pramoxine: Local anesthetic that stabilizes neuronal membranes to reduce itch and pain signal transmission.

Calamine: Mild astringent and skin protectant; soothes and dries irritated skin.

Pharmacokinetics: Minimal systemic absorption when applied topically on intact skin.

Dosage & Administration ▼

Patient Category	Recommended Application	Max / 24h
Adults	Apply thin layer 3–4 times daily	As needed
Children ≥2 years	Apply 3–4 times daily	As needed
Children <2 years	Use under medical advice	As directed

Note: Shake lotion before use. Apply on clean, dry skin. Avoid eyes, mouth, and broken skin.

Side Effects ▼

Mild skin irritation

Redness or dryness

Rare hypersensitivity reactions

Contraindications ▼

Hypersensitivity to pramoxine or calamine

Do not apply on deep wounds or severe burns

Drug Interaction ▼

No significant systemic interactions expected

Avoid concurrent use with other topical irritants on same area

Pregnancy & Lactation ▼

Generally safe for topical use in pregnancy

Avoid applying to breastfeeding area before feeding

Clinical / Research Summary ▼

Effective in relieving mild to moderate pruritus and irritation.

Safe topical option with minimal systemic absorption.

Provides both anesthetic and protective effect on skin surface.

Patient Counseling Points ▼

External use only

Stop use if irritation worsens

Consult a physician if symptoms persist beyond 7 days

Storage & Handling ▼

Store below 30°C

Protect from direct sunlight

Keep container tightly closed

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Itchsol® 1%+3% Cream Itchnil® 1%+3% Cream

Global:

Caladryl® Pramoxine + Calamine

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Topical Antipruritics • Condition: Skin Irritation • Clinical Evidence & Trials