Paracetamol + Tramadol Hydrochloride | MedexInfo

Paracetamol + Tramadol Hydrochloride

Rx Only

Generic NameParacetamol + Tramadol HCl

Therapeutic ClassAnalgesic Combination (Opioid + Non-Opioid)

Common Dose1 tablet every 6–8 hours

Max / 24h8 tablets (depending on strength)

PregnancyCategory C

Indications ▼

Moderate to severe acute pain (postoperative, musculoskeletal, trauma)

Chronic pain requiring combination therapy

Pain not adequately controlled with paracetamol alone

Mechanism & Pharmacokinetics ▼

Mechanism: Paracetamol inhibits central prostaglandin synthesis producing analgesic effect. Tramadol is a weak μ-opioid receptor agonist and inhibits norepinephrine and serotonin reuptake, enhancing analgesia.

Pharmacokinetics: Both drugs rapidly absorbed orally. Tramadol metabolized in liver via CYP2D6 to active metabolite; excreted mainly via urine. Paracetamol metabolized via glucuronidation and sulfation. Half-life: Paracetamol 2–3 h, Tramadol 6–7 h.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	1 tablet every 6–8 hours	8 tablets/day (depends on strength)
Elderly	Start with 1 tablet every 8 hours; adjust for renal/hepatic impairment	≤6 tablets/day
Children	Not recommended for <12 years (risk of opioid toxicity)	N/A
Hepatic/Renal Impairment	Reduce dose and monitor closely	As per physician guidance

Note: Take with water. Avoid concomitant use with other CNS depressants. Do not exceed recommended dose. Use lowest effective dose for shortest duration.

Side Effects ▼

Common: Nausea, dizziness, constipation, headache

Occasional: Somnolence, sweating, dry mouth

Rare: Seizures, severe allergic reactions, respiratory depression (especially in overdose)

Contraindications ▼

Hypersensitivity to paracetamol or tramadol

Respiratory depression or severe asthma

Paralytic ileus

Concurrent MAO inhibitors (within 14 days)

Drug Interaction ▼

CNS depressants: additive sedation (alcohol, benzodiazepines)

SSRIs/SNRIs: risk of serotonin syndrome with tramadol

Other opioids: increased risk of respiratory depression

Warfarin: monitor INR

Pregnancy & Lactation ▼

Category C; use only if benefit outweighs risk

Excreted in breast milk; avoid in nursing infants if possible

Clinical / Research Summary ▼

Combination therapy provides superior analgesia compared to paracetamol alone.

Effective for moderate to severe acute pain; reduces need for additional opioids.

Monitor for signs of opioid dependence or misuse during prolonged therapy.

Patient Counseling Points ▼

Take exactly as prescribed; do not exceed recommended dose.

Avoid alcohol or other CNS depressants.

Report dizziness, breathing difficulty, or severe constipation immediately.

Store safely out of reach of children.

Storage & Handling ▼

Store at room temperature, away from moisture and light

Keep tablets in original container

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

NapaDol® 325 mg+37.5 mg Acetram® 325 mg+37.5 mg Anadol Plus® 325 mg+37.5 mg Atopen-X® 325 mg+37.5 mg Dolceta® 325 mg+37.5 mg Doloran Plus® 325 mg+37.5 mg Fapdol® 325 mg+37.5 mg Fastdol® 325 mg+37.5 mg Fevedol® 325 mg+37.5 mg NorDol® 325 mg+37.5 mg Novodol® 325 mg+37.5 mg P-Dol® 325 mg+37.5 mg Pangesic® 325 mg+37.5 mg Paratadol® 325 mg+37.5 mg Prodol® 325 mg+37.5 mg Resadol® 325 mg+37.5 mg Syndol Plus® 325 mg+37.5 mg TacsDol® 325 mg+37.5 mg Tamenol® 325 mg+37.5 mg Trado Plus® 325 mg+37.5 mg Tramatol® 325 mg+37.5 mg Tramp® 325 mg+37.5 mg Trixotim® 325 mg+37.5 mg Utracet® 325 mg+37.5 mg Xcel Max® 325 mg+37.5 mg

Global:

Ultracet®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Analgesics • Condition: Pain Management