Paracetamol + Caffeine
OTC / Rx
Generic NameParacetamol + Caffeine
Therapeutic ClassAnalgesic Combination
Common Dose1 tablet every 6 hours as needed
Max / 24h4–6 tablets (depending on strength)
PregnancyCategory B
Indications ▼
Headache, including tension-type and mild migraine
Fever and mild pain (toothache, musculoskeletal pain)
Situations where paracetamol alone is insufficient for analgesia
Mechanism & Pharmacokinetics ▼
Mechanism: Paracetamol inhibits central prostaglandin synthesis providing analgesic and antipyretic effects. Caffeine acts as a central nervous system stimulant and enhances analgesic effect of paracetamol.
Pharmacokinetics: Rapid oral absorption. Paracetamol metabolized via glucuronidation and sulfation in liver. Caffeine metabolized by CYP1A2; excreted mainly in urine. Half-life: Paracetamol 2–3 h, Caffeine 3–7 h.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults | 1 tablet every 6 hours as needed | 4–6 tablets/day (depending on formulation) |
| Elderly | Start with 1 tablet every 6–8 hours; monitor for caffeine-related effects | 4 tablets/day |
| Children (≥12 years) | Use pediatric strength formulations only; follow physician guidance | As prescribed |
| Hepatic Impairment | Use with caution; avoid exceeding recommended dose | As per physician guidance |
Note: Take with water. Avoid other caffeine-containing products. Do not exceed recommended dose. Monitor for insomnia, palpitations, or anxiety.
Side Effects ▼
Common: Nausea, headache, restlessness, insomnia
Occasional: Palpitations, mild anxiety
Rare: Severe allergic reactions, hepatotoxicity (if overdose)
Contraindications ▼
Hypersensitivity to paracetamol or caffeine
Severe liver disease
Severe cardiac arrhythmias or uncontrolled hypertension (due to caffeine)
Drug Interaction ▼
Other CNS stimulants: increased risk of insomnia, palpitations
Alcohol: additive hepatotoxic risk with paracetamol
Warfarin: monitor INR with prolonged paracetamol use
Enzyme inducers: may alter metabolism of caffeine
Pregnancy & Lactation ▼
Category B; safe at recommended doses
Excreted in breast milk in small amounts; generally considered safe
Clinical / Research Summary ▼
Combination enhances analgesic effect compared to paracetamol alone.
Effective for tension-type headaches, mild migraines, and other mild to moderate pain.
Monitor for caffeine-related side effects in sensitive individuals.
Patient Counseling Points ▼
Do not exceed recommended dose.
Avoid additional caffeine-containing products.
Report palpitations, anxiety, or insomnia if persistent.
Use caution in children and elderly patients.
Storage & Handling ▼
Store at room temperature, away from moisture and light
Keep tablets in original container
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Bangladesh:
Ace Plus® 500+65 mg
A‑One Plus® 500+65 mg
Acep Extra® 500+65 mg
Aceta‑X® 500+65 mg
Adol Plus® 500+65 mg
Alpa Extra® 500+65 mg
Ampol Plus® 500+65 mg
Asta Plus® 500+65 mg
Atopen Plus® 500+65 mg
ATP Extra® 500+65 mg
Benalgin Plus® 500+65 mg
Cafecool Plus® 500+65 mg
Phoenix Paracetamol Plus® 500+65 mg
Tylen Plus® 500+65 mg
Paracet Plus® 500+65 mg
Pyrenol® 500+65 mg
Global:
Ace Plus® 500+65 mg
Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider.
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