Paracetamol 665 mg: Uses, Dosage, Side Effects & Brands | MedexInfo

Paracetamol 665 mg

OTC / Rx

Generic NameParacetamol

Therapeutic ClassAnalgesic, Antipyretic

Common Dose665 mg every 6–8 hours

Max / 24h3990 mg

PregnancyCategory B

Indications ▼

Mild to moderate pain (headache, toothache, musculoskeletal pain)

Fever

Cold and flu symptoms

Postoperative pain

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits central prostaglandin synthesis producing analgesic and antipyretic effects; minimal anti-inflammatory activity.

Pharmacokinetics: Rapid oral absorption; metabolized in liver via glucuronidation and sulfation. Small fraction converted to toxic metabolite NAPQI, detoxified by glutathione. Half-life 2–3 hours; excreted in urine.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	665 mg every 6–8 hours	3990 mg
Elderly	Same as adults; avoid high doses in liver impairment	3990 mg
Children	10–15 mg/kg per dose every 6–8 hours	60–75 mg/kg/day

Note: Do not exceed maximum daily dose. Avoid combination with other paracetamol-containing products. Use with caution in hepatic impairment.

Side Effects ▼

Common: Nausea, mild rash

Occasional: Elevated liver enzymes

Rare: Hepatotoxicity in overdose, severe skin reactions (SJS/TEN)

Contraindications ▼

Severe hepatic impairment

Hypersensitivity to paracetamol

Chronic alcoholism (use cautiously)

Drug Interaction ▼

Alcohol increases risk of hepatotoxicity

Warfarin: monitor INR with prolonged use

Enzyme inducers (rifampicin, carbamazepine) increase hepatotoxic risk

Pregnancy & Lactation ▼

Category B; safe at recommended doses

Compatible with breastfeeding in standard doses

Clinical / Research Summary ▼

Widely used analgesic and antipyretic with rapid onset of action.

Safer GI profile compared to NSAIDs.

Overdose may cause acute liver failure; N-acetylcysteine is effective antidote.

Patient Counseling Points ▼

Do not exceed daily maximum dose.

Check other medicines for hidden paracetamol content.

Seek medical help immediately in case of overdose.

Avoid alcohol during treatment.

Storage & Handling ▼

Store below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Ace XR® 665 mg Paratam Extend® 665 mg Parajor XR® 665 mg ATP XR® 665 mg Aceta Extend® 665 mg Xpa XR® 665 mg Pyrenol XR® 665 mg

Global:

Tylenol 665® Acetaminophen 665 mg (Generic)

Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider.

Reference Hubs:

• Drug Class: Analgesics • Condition: Fever • Clinical Evidence & Safety