Olmesartan Medoxomil: Uses, Dosage, Side Effects & Brands | MedexInfo

Olmesartan Medoxomil

Rx Only

Generic NameOlmesartan Medoxomil

Therapeutic ClassAngiotensin II Receptor Blocker (ARB)

Common Dose20–40 mg once daily

Max / 24h40 mg

PregnancyCategory D

Indications ▼

Hypertension (high blood pressure)

Reduction of cardiovascular risk in hypertensive patients

Mechanism & Pharmacokinetics ▼

Mechanism: Selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release, thereby lowering blood pressure.

Pharmacokinetics: Prodrug converted to active olmesartan; peak plasma levels in 1–2 hours; bioavailability ~26%; eliminated via feces and urine; half-life ~13 hours.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	Start 20 mg once daily; may increase to 40 mg daily	40 mg
Elderly	Start at lower dose; monitor renal function	40 mg
Children ≥6 years	10–20 mg once daily depending on weight	40 mg

Note: Can be taken with or without food. Monitor blood pressure and renal function regularly.

Side Effects ▼

Dizziness, headache

Hypotension

Hyperkalemia

Rare: sprue-like enteropathy (chronic diarrhea, weight loss)

Contraindications ▼

Pregnancy (especially second and third trimester)

Bilateral renal artery stenosis

Hypersensitivity to olmesartan

Drug Interaction ▼

Potassium supplements or potassium-sparing diuretics increase hyperkalemia risk

NSAIDs may reduce antihypertensive effect and impair renal function

Other antihypertensives may enhance hypotensive effect

Pregnancy & Lactation ▼

Contraindicated in pregnancy due to fetal toxicity risk

Use caution during lactation; limited safety data

Clinical / Research Summary ▼

Effective once-daily ARB for hypertension control

Favorable tolerability compared to ACE inhibitors

Long half-life supports consistent BP control

Patient Counseling Points ▼

Take regularly at the same time each day

Avoid potassium-rich supplements unless advised

Report dizziness, fainting, or persistent diarrhea

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Olmesartan Tablets

Global:

Benicar® Olmesartan Medoxomil

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: ARBs • Condition: Hypertension • Pathway: Angiotensin II Receptor Blockade • Clinical Evidence & Trials