Olmesartan Medoxomil + Hydrochlorothiazide (HCTZ) | MedexInfo

Olmesartan Medoxomil + Hydrochlorothiazide (HCTZ)

Rx Only

Generic NameOlmesartan Medoxomil + Hydrochlorothiazide

Therapeutic ClassARB + Thiazide Diuretic

Common Dose20/12.5 mg or 40/12.5 mg once daily

Max / 24h40/25 mg

PregnancyCategory D

Indications ▼

Hypertension not adequately controlled with monotherapy

Reduction of cardiovascular risk in hypertensive patients

Mechanism & Pharmacokinetics ▼

Mechanism: Olmesartan blocks angiotensin II (AT1) receptors causing vasodilation; Hydrochlorothiazide increases sodium and water excretion via inhibition of sodium reabsorption in distal tubules, reducing plasma volume and blood pressure.

Pharmacokinetics: Olmesartan is a prodrug converted in GI tract; HCTZ absorbed orally; peak levels within 1–2 hours; elimination via renal excretion; additive antihypertensive effect.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	Start 20/12.5 mg once daily; may increase to 40/25 mg	40/25 mg
Elderly	Start at lower dose; monitor renal function and electrolytes	40/25 mg
Children	Not routinely recommended	—

Note: Take once daily with or without food. Monitor blood pressure, renal function, and electrolytes.

Side Effects ▼

Dizziness, hypotension

Electrolyte imbalance (hypokalemia, hyponatremia)

Hyperuricemia, increased blood glucose

Fatigue, headache

Contraindications ▼

Pregnancy (contraindicated)

Anuria or severe renal impairment

Hypersensitivity to sulfonamides or ARBs

Drug Interaction ▼

NSAIDs may reduce antihypertensive effect

Potassium supplements or diuretics alter potassium levels

Lithium toxicity risk increased

Pregnancy & Lactation ▼

Contraindicated in pregnancy due to fetal toxicity

Avoid during breastfeeding unless clearly needed

Clinical / Research Summary ▼

Combination provides superior BP reduction compared to monotherapy

Improves compliance with once-daily fixed-dose regimen

Widely recommended in hypertension guidelines

Patient Counseling Points ▼

Take regularly at the same time each day

Monitor blood pressure and electrolyte levels

Report dizziness, dehydration, or muscle weakness

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Olmesartan + HCTZ Tablets

Global:

Benicar HCT® Olmesartan + Hydrochlorothiazide

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: ARB Combinations • Condition: Hypertension • Pathway: RAAS Blockade + Diuretic Effect • Clinical Evidence & Trials