Tioconazole: Uses, Dosage, Side Effects & Brands | MedexInfo

Tioconazole

OTC / Rx

Generic NameTioconazole

Therapeutic ClassTopical Antifungal (Imidazole)

Common DoseVaginal cream: 1 applicator (6.5% cream) once at bedtime

PregnancyUse only if clearly needed; consult physician

Indications ▼

Vaginal candidiasis (single-dose therapy for uncomplicated infection)

Topical treatment of cutaneous fungal infections (e.g., ringworm, athlete’s foot)

Alternative for patients intolerant to other azoles

Mechanism & Pharmacokinetics ▼

Mechanism: Tioconazole inhibits fungal lanosterol 14α-demethylase, an enzyme involved in ergosterol synthesis. This disrupts fungal cell membrane formation, leading to cell death.

Pharmacokinetics: Minimal systemic absorption when used topically or intravaginally. Metabolism and excretion not clinically significant due to local administration.

Dosage & Administration ▼

Indication	Form	Dose	Frequency
Vaginal candidiasis	6.5% vaginal cream	1 applicator	Once at bedtime
Cutaneous fungal infection	Topical cream / ointment	Apply thin layer	Twice daily for 2–4 weeks

Note: Complete full course; avoid intercourse during vaginal treatment for yeast infection. Wash hands before and after topical application.

Side Effects ▼

Local burning, itching, or irritation

Redness or swelling at application site

Rare: hypersensitivity reactions (rash, urticaria)

Contraindications ▼

Hypersensitivity to tioconazole or other imidazole antifungals

Severe liver impairment (topical systemic absorption rare, but caution advised)

Drug Interaction ▼

Minimal systemic interactions; avoid concurrent use with other intravaginal medications unless approved

Oral azoles may interact with CYP3A4 substrates; topical use unlikely to cause systemic effects

Pregnancy & Lactation ▼

Use only if clearly needed; consult physician

Topical use is preferred over oral azoles during pregnancy

Breastfeeding: limited data; avoid direct application on nipple

Clinical / Research Summary ▼

Clinical Role: Effective topical antifungal for uncomplicated vaginal yeast infections and cutaneous fungal infections.

Advantage: Single-dose vaginal therapy improves adherence; minimal systemic absorption reduces risk of systemic side effects.

Monitoring: Observe for local irritation or allergic reactions; seek medical advice if symptoms persist >7 days.

Patient Counseling Points ▼

Apply as directed, complete full course

Avoid sexual intercourse during vaginal treatment

Wash hands before and after application

Report persistent irritation, discharge, or allergy

Storage & Handling ▼

Store below 25°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Conasyd® 1% Cream Suconal® 1% Cream Tycon® 1% Cream Tiozol® 6.5% Ointment Tycon® 300 mg Suppository

Global:

Gyno-Tiocol Monistat-Tioc

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Antifungals (Imidazoles) • Condition: Vaginal Candidiasis • Condition: Fungal Skin Infections