Tiotropium: Uses, Dosage, Side Effects & Brands | MedexInfo

Tiotropium

Rx

Generic NameTiotropium

Therapeutic ClassLong-acting Muscarinic Antagonist (LAMA)

Common DoseInhalation: 18 mcg once daily (powder), 2.5 mcg once daily (solution)

PregnancyUse only if clearly needed

Indications ▼

Chronic obstructive pulmonary disease (COPD) – maintenance therapy

Asthma (add-on maintenance therapy in adults)

Prevention of bronchospasm and reduction of exacerbations in COPD

Mechanism & Pharmacokinetics ▼

Mechanism: Tiotropium is a long-acting muscarinic antagonist. It blocks M3 receptors in airway smooth muscle, causing bronchodilation and reduced mucus secretion.

Pharmacokinetics: Inhaled drug acts locally; minimal systemic absorption. Peak plasma levels 5–7 minutes after inhalation; eliminated mainly via renal excretion. Half-life ~25 hours.

Dosage & Administration ▼

Indication	Form	Dose	Frequency
COPD maintenance	Inhalation powder (HandiHaler)	18 mcg	Once daily
COPD maintenance	Inhalation solution (Respimat)	2.5 mcg	Once daily
Asthma add-on	Inhalation solution	2.5 mcg	Once daily

Note: Use daily at the same time. Not for acute bronchospasm relief. Shake and prime inhaler as instructed.

Side Effects ▼

Dry mouth

Throat irritation, cough

Constipation, urinary retention

Tachycardia, palpitations (rare)

Allergic reactions (rash, angioedema – rare)

Contraindications ▼

Hypersensitivity to tiotropium or other anticholinergics

Urinary retention, bladder neck obstruction, or severe prostatic hypertrophy

Glaucoma (narrow-angle, untreated)

Drug Interaction ▼

Other anticholinergics: additive dry mouth, constipation, urinary retention

Beta-agonists or other bronchodilators: generally safe, can be combined

Pregnancy & Lactation ▼

Use only if clearly needed; limited human data

Breastfeeding: use with caution; minimal excretion in milk

Clinical / Research Summary ▼

Clinical Role: Long-acting bronchodilator for maintenance therapy in COPD and adjunct in asthma.

Advantage: Once-daily dosing improves adherence; minimal systemic side effects.

Monitoring: Lung function, symptom relief, dry mouth, urinary symptoms.

Patient Counseling Points ▼

Use inhaler daily at the same time; not for acute attacks

Rinse mouth after inhalation to reduce dry mouth and irritation

Report urinary retention, palpitations, or severe allergic reactions

Maintain follow-up with physician for lung function assessment

Storage & Handling ▼

Store below 30°C, keep inhaler dry

Do not freeze; protect from moisture and dust

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Spiriva Tiopres

Global:

Spiriva Tiova

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Long-acting Muscarinic Antagonists (LAMA) • Condition: COPD • Condition: Asthma