Tigecycline
Rx
Generic NameTigecycline
Therapeutic ClassGlycylcycline Antibiotic
Common DoseInitial: 100 mg IV, then 50 mg IV every 12 hours
PregnancyUse only if clearly needed
Indications ▼
Complicated skin and soft tissue infections (cSSTI)
Complicated intra-abdominal infections (cIAI)
Community-acquired bacterial pneumonia (CABP)
Infections caused by multidrug-resistant Gram-positive and Gram-negative organisms
Mechanism & Pharmacokinetics ▼
Mechanism: Tigecycline binds to the 30S ribosomal subunit, inhibiting protein synthesis and preventing bacterial growth. It is bacteriostatic.
Pharmacokinetics: IV administration; extensively distributed in tissues; half-life ~42 hours; primarily eliminated via biliary/fecal excretion, minimal renal excretion.
Dosage & Administration ▼
| Indication | Dose | Frequency |
|---|---|---|
| cSSTI, cIAI | 100 mg IV loading, then 50 mg IV | Every 12 hours |
| CABP | 100 mg IV loading, then 50 mg IV | Every 12 hours |
Note: Adjust dose in severe hepatic impairment (Child-Pugh C). Not recommended in renal impairment dose adjustment.
Side Effects ▼
Nausea, vomiting (common)
Diarrhea
Abdominal pain, dyspepsia
Elevated liver enzymes (ALT, AST)
Rare: pancreatitis, hypersensitivity reactions, thrombocytopenia
Contraindications ▼
Hypersensitivity to tigecycline or tetracyclines
Pregnancy or breastfeeding unless clearly needed (risk of tooth discoloration in fetus/infant)
Drug Interaction ▼
No major CYP-mediated interactions, but avoid co-administration with strong CYP3A inducers (may reduce effectiveness)
May enhance anticoagulant effects (monitor INR with warfarin)
Absorption of oral tetracyclines or divalent cations may interfere if taken simultaneously
Pregnancy & Lactation ▼
Use only if clearly needed; may cause fetal tooth/bone effects
Breastfeeding not recommended
Clinical / Research Summary ▼
Clinical Role: Broad-spectrum IV antibiotic for complicated skin, abdominal infections, and CABP, including multidrug-resistant pathogens.
Advantage: Effective against MRSA, VRE, and resistant Gram-negative organisms.
Monitoring: Liver function, coagulation profile, electrolytes; watch for nausea and infusion-related effects.
Patient Counseling Points ▼
Administer IV as prescribed; complete full course
Report persistent nausea, vomiting, or diarrhea
Inform physician about liver disease or co-medications
Not recommended during pregnancy/breastfeeding unless necessary
Storage & Handling ▼
Store below 25°C, protect from light
Reconstituted solution: 25°C up to 24h, or 2–8°C up to 48h
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Bangladesh:
Global:
Tegalon® 50 mg/vial
Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.
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