Tazarotene
Rx
Generic NameTazarotene
Therapeutic ClassTopical Retinoid
Max / 24hApply once daily (gel/cream)
Common DoseApply 0.05–0.1% once daily to affected area
PregnancyContraindicated (Category X)
Indications ▼
Psoriasis (mild to moderate plaque-type)
Acne vulgaris
Photoaging and sun-damaged skin
Mechanism & Pharmacokinetics ▼
Mechanism: Tazarotene is a selective retinoic acid receptor agonist that modulates gene expression, normalizes keratinocyte differentiation, and reduces inflammation.
Pharmacokinetics: Minimal systemic absorption when applied topically. Metabolized rapidly to tazarotenic acid and excreted mainly in urine. Peak plasma levels <2 hours post-application.
Dosage & Administration ▼
| Condition | Recommended Dose | Frequency |
|---|---|---|
| Psoriasis | 0.05–0.1% gel/cream | Apply once daily to affected areas |
| Acne | 0.05% gel/cream | Apply once daily at bedtime |
| Photoaging | 0.05% gel/cream | Apply once daily at night |
Note: Avoid sensitive areas such as eyes, mouth, and mucous membranes. Use sunscreen during the day.
Side Effects ▼
Local irritation: erythema, burning, stinging, itching
Dryness, peeling, or scaling of skin
Photosensitivity
Rare: allergic contact dermatitis
Contraindications ▼
Pregnancy (Category X)
Hypersensitivity to tazarotene or any component of the formulation
Open wounds or eczema at application site
Drug Interaction ▼
Concurrent use with other topical retinoids or irritants may increase local irritation
Photosensitizing agents may increase sunburn risk
Pregnancy & Lactation ▼
Contraindicated in pregnancy due to teratogenicity
Not recommended during breastfeeding
Clinical / Research Summary ▼
Therapeutic Role: Effective topical retinoid for psoriasis, acne, and photoaging.
Clinical Effectiveness: Reduces lesion severity, inflammation, and hyperkeratosis; improves skin texture and pigmentation.
Safety Profile: Primarily local irritation; minimal systemic absorption; monitor for pregnancy.
Current Research: Optimizing formulation for reduced irritation and enhanced adherence; combination therapy with emollients and sunscreen.
Patient Counseling Points ▼
Apply thin layer once daily to affected area
Avoid eyes, mouth, mucous membranes, and broken skin
Use sunscreen and limit sun exposure
Do not use if pregnant or planning pregnancy
Wash hands after application
Storage & Handling ▼
Store at 20–25°C, protect from light
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Tazoskin® 0.1%
Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.
Reference Hubs:
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