Amoxicillin
Rx Only
GenericAmoxicillin
Therapeutic ClassPenicillin Antibiotic
Common Dose250–500 mg every 8 hours or 500–875 mg every 12 hours
Max / 24h3000 mg
PregnancyCategory B
Indications ▼
Respiratory tract infections (sinusitis, bronchitis, pneumonia)
Otitis media
Skin and soft tissue infections
Urinary tract infections
H. pylori eradication (combined with other drugs)
Mechanism & Pharmacokinetics ▼
Mechanism: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, leading to cell lysis and death.
Pharmacokinetics: Well absorbed orally; peak plasma concentration in 1–2 hours; partially metabolized in liver; excreted mostly unchanged in urine; half-life ~1 hour.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults | 250–500 mg every 8 hours or 500–875 mg every 12 hours | 3000 mg |
| Children | 20–40 mg/kg/day in divided doses every 8–12 hours | – |
Side Effects ▼
Common: Diarrhea, nausea, vomiting, rash
Rare: Stevens-Johnson syndrome, anaphylaxis, liver enzyme elevations
Contraindications ▼
Hypersensitivity to penicillins or other beta-lactam antibiotics
History of severe allergic reactions to cephalosporins (caution)
Drug Interaction ▼
Allopurinol: may increase risk of rash
Oral contraceptives: may reduce efficacy
Warfarin: may enhance anticoagulant effect
Pregnancy & Lactation ▼
Generally considered safe in pregnancy (Category B)
Compatible with breastfeeding
Clinical / Research Summary ▼
Effectiveness: Broad-spectrum activity against Gram-positive and some Gram-negative bacteria, widely used for community and hospital infections.
Resistance Considerations: Monitor for bacterial resistance; combine with clavulanic acid for beta-lactamase producing strains.
Tolerability: Generally well tolerated; gastrointestinal upset is most common side effect.
Clinical Studies: Extensive studies confirm efficacy in upper/lower respiratory infections, otitis media, and UTI management.
Storage & Handling ▼
Store at 15–30°C; protect from moisture & light
Keep out of reach of children
Patient Counseling Points ▼
How to take: Take at evenly spaced intervals; can be taken with or without food.
Missed dose: Take as soon as possible; do not double dose.
Side effects: Mild diarrhea, nausea, or rash may occur; seek medical attention for severe allergic reactions.
Drug interactions: Inform your doctor about all medications, especially anticoagulants or oral contraceptives.
Duration of therapy: Complete the full course even if symptoms improve early.
Brand Names (Bangladesh & Global) ▼
Amoxil
Amoclav
Moxil
Amox
Ospamox
Amoxil
Moxatag
Trimox
Amoxicot
Amoxicillin Sandoz
Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.
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