Amoxicillin + Clavulanate: Dosage, Side Effects, Clinical Use | MedexInfo

Amoxicillin + Clavulanate

Rx Only

Therapeutic ClassBeta-lactam Antibiotic

Common Dose500/125 mg or 875/125 mg

Max / 24h1 g (Adults)

PregnancyCategory B

Indications ▼

Respiratory tract infections

Urinary tract infections

Skin & soft tissue infections

ENT infections

H. pylori eradication (with antibiotics)

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits bacterial cell wall synthesis leading to bacterial lysis.

Pharmacokinetics: Oral absorption Tmax ~1 hr; widely distributed; excreted primarily via urine; half-life ~1 hr.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	500/125 mg every 8 h or 875/125 mg every 12 h	1 g
Children	25–45 mg/kg/day divided every 8–12 h	–

Side Effects ▼

Common: Nausea, diarrhea, rash

Rare: Hepatic dysfunction, hypersensitivity reactions

Serious: Anaphylaxis (immediate medical attention required)

Contraindications ▼

Hypersensitivity to penicillins or beta-lactams

Severe renal impairment

Drug Interaction ▼

Allopurinol: may increase rash incidence

Oral contraceptives: may reduce effectiveness

Pregnancy & Lactation ▼

Generally safe in pregnancy (Category B)

Compatible with breastfeeding

Clinical / Research Summary ▼

Effective against various bacterial infections

Generally well tolerated in adults and children

Overdose can cause serious toxicity; follow medical guidance

Patient Counseling Points ▼

Complete full course of therapy even if symptoms improve

Avoid skipping doses

Report signs of allergic reaction immediately

Storage & Handling ▼

Store at 15–25°C; protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh (Local Brands):

Clavomox Augmentin Amoxil Plus Moxyclav Clavomox-F Amoclav Clavocid Augmox Amoxclav Moxclav Clavoclav Clavopen Amoxigen Moxipen Clavamox Amoxyclav Clavamax Augclav Clavulin Amoxclav-F

Global / International Brands:

Augmentin Clavulin Amoxiclav Augmex Amoxyclav Clavomox Augmox Amoclav Moxyclav Clavocid Clavogen Amoxen Clavox Augclav Clavamox Moxiclav Amoxiclav Duo Clavun Amoxyn Clavamax

Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.

Reference Hubs:

• Drug Class: Antibiotics • Conditions: Bacterial Infections • Pathway: Cell Wall Synthesis Inhibition