Amlodipine + Olmesartan Medoxomil: Uses, Dosage, Side Effects | MedexInfo
Labels:
Calcium Channel Blocker + ARB
Amlodipine + Olmesartan Medoxomil
Rx Only
Therapeutic ClassCalcium Channel Blocker + ARB
Common DoseAmlodipine 5–10 mg + Olmesartan 20–40 mg daily
Max / 24hIndividualized per patient response
PregnancyCategory D
Indications ▼
Essential hypertension
Patients not adequately controlled with monotherapy
Adjunct therapy for cardiovascular risk reduction in hypertensive patients
Mechanism & Pharmacokinetics ▼
Mechanism: Amlodipine relaxes vascular smooth muscle, reducing peripheral resistance. Olmesartan blocks angiotensin II type 1 receptors, reducing vasoconstriction and aldosterone secretion.
Pharmacokinetics: Amlodipine: oral Tmax 6–12 hr, metabolized in liver. Olmesartan: oral Tmax 1–2 hr, metabolized to active form, excreted in urine and feces; half-life ~13 hr.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults | Amlodipine 5–10 mg + Olmesartan 20–40 mg once daily | Individualized |
| Elderly | Start at lower dose, titrate as tolerated | Individualized |
Side Effects ▼
Common: Dizziness, headache, peripheral edema, fatigue
Serious: Hyperkalemia, hypotension, angioedema, kidney impairment
Contraindications ▼
History of angioedema related to ARBs
Severe hypotension
Pregnancy (2nd/3rd trimester)
Drug Interaction ▼
Potassium supplements: risk of hyperkalemia
NSAIDs: may reduce antihypertensive effect or worsen kidney function
Other antihypertensives: additive hypotension
Pregnancy & Lactation ▼
Contraindicated in pregnancy, especially 2nd/3rd trimester (Category D)
Use during breastfeeding only if benefits outweigh risks
Clinical / Research Summary ▼
Blood Pressure Control: Combination therapy reduces systolic and diastolic BP more effectively than either agent alone.
Cardiovascular Outcomes: Evidence suggests improved outcomes in hypertensive patients at risk of cardiovascular events.
Tolerability: Well tolerated; peripheral edema and hypotension are dose-limiting side effects.
Pharmacogenomics: ARB response may vary depending on RAAS pathway polymorphisms.
Storage & Handling ▼
Store at 15–30°C; protect from moisture & light
Keep out of reach of children
Patient Counseling Points ▼
How to take: Take at the same time each day, with or without food.
Missed dose: Take as soon as remembered unless near next dose; do not double dose.
Monitor: Blood pressure and kidney function regularly.
Lifestyle: Low-salt diet, exercise, avoid smoking and excess alcohol.
Side effects: Report swelling of face/lips, persistent cough, dizziness, or fainting.
Drug interactions: Inform your doctor about all medications, especially potassium supplements, NSAIDs, or other antihypertensives.
Brand Names (Bangladesh & Global) ▼
Amlomed-O
Olmecal-A
Azor
Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.
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