Amlodipine + Benazepril: Uses, Dosage, Side Effects & Brands | MedexInfo
Amlodipine + Benazepril
Rx Only
Therapeutic ClassCalcium Channel Blocker + ACE Inhibitor
Common DoseAmlodipine 5–10 mg + Benazepril 10–20 mg daily
Max / 24hDependent on patient response
PregnancyCategory D
Indications ▼
Essential hypertension
Hypertension with cardiovascular risk factors
Adjunct therapy for patients inadequately controlled with monotherapy
Mechanism & Pharmacokinetics ▼
Mechanism: Amlodipine relaxes vascular smooth muscle to lower blood pressure. Benazepril inhibits ACE, reducing angiotensin II and aldosterone, further lowering BP.
Pharmacokinetics: Amlodipine: oral Tmax ~6–12 hr, metabolized in liver; Benazepril: oral Tmax 1 hr, converted to active metabolite, excreted in urine.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults | Amlodipine 5–10 mg + Benazepril 10–20 mg once daily | Individualized |
| Elderly | Start low, titrate based on response | Individualized |
Side Effects ▼
Common: Dizziness, headache, peripheral edema, fatigue
Serious: Hyperkalemia, hypotension, angioedema, kidney impairment
Contraindications ▼
History of angioedema related to ACE inhibitors
Severe hypotension
Pregnancy (especially 2nd/3rd trimester)
Drug Interaction ▼
Potassium supplements: risk of hyperkalemia
NSAIDs: may reduce antihypertensive effect
Other antihypertensives: additive hypotension
Pregnancy & Lactation ▼
Contraindicated in pregnancy, especially 2nd/3rd trimester (Category D)
Use during breastfeeding only if benefits outweigh risks
Clinical / Research Summary ▼
Blood Pressure Control: Combination therapy more effective than monotherapy in reducing systolic and diastolic BP.
Cardiovascular Outcomes: Shown to reduce risk of stroke, heart failure, and other CV events in hypertensive patients.
Tolerability: Generally well tolerated; peripheral edema from amlodipine may limit dose escalation.
Pharmacogenomics: ACE inhibitor response may vary with genetic polymorphisms affecting RAAS pathway.
Patient Counseling Points ▼
How to take: Take at the same time each day, with or without food.
Missed dose: Take as soon as remembered unless near next dose; do not double dose.
Monitor: Regular BP checks and kidney function monitoring recommended.
Lifestyle: Low-salt diet, exercise, avoid smoking and excessive alcohol.
Side effects: Report swelling of face/lips, persistent cough, or dizziness.
Drug interactions: Inform provider about other medications, especially potassium supplements or NSAIDs.
Storage & Handling ▼
Store at 15–30°C; protect from moisture & light
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Amben
Benazepril-Amlodipine
Lotrel
Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.
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