Amlodipine + Atenolol: Uses, Dosage, Side Effects & Brands | MedexInfo
Amlodipine 5 mg + Atenolol 50 mg
Rx Only
Therapeutic ClassAntihypertensive Combination
Common DoseOne tablet daily
Max / 24h2 Tablets
PregnancyCategory D
Indications ▼
Essential Hypertension (High Blood Pressure)
Chronic Stable Angina Pectoris
Co-existing Hypertension and Angina
Post-Myocardial Infarction stabilization
Mechanism & Pharmacokinetics ▼
Amlodipine: A dihydropyridine calcium channel blocker that relaxes vascular smooth muscle, leading to peripheral vasodilation and reduced blood pressure.
Atenolol: A cardioselective beta-1 adrenergic blocker that reduces heart rate, cardiac output, and blood pressure.
Pharmacokinetics: Amlodipine has a long half-life (~30–50h) and steady-state absorption. Atenolol is absorbed incompletely from the GI tract and excreted primarily unchanged by the kidneys.
Dosage & Administration ▼
| Condition | Recommended Dose | Max / 24h |
|---|---|---|
| Hypertension | One tablet (5/50) daily | 2 Tablets |
| Angina Pectoris | One tablet (5/50) daily | 2 Tablets |
| Elderly | Start with lower dose (if available) | - |
*Dosing should be individualized based on patient response.
Side Effects ▼
Common: Edema (swelling of ankles), fatigue, dizziness, headache, nausea
Cardiovascular: Bradycardia (slow heart rate), cold extremities, palpitations
Respiratory: Dyspnea (shortness of breath)
Rare: Sleep disturbances, depression, visual impairment
Contraindications ▼
Hypersensitivity to Amlodipine, Atenolol, or other beta-blockers/CCBs
Sinus bradycardia, second or third-degree heart block
Cardiogenic shock and overt cardiac failure
Severe peripheral arterial circulatory disorders
Drug Interaction ▼
Calcium Channel Blockers (Verapamil/Diltiazem): Increased risk of bradycardia and heart block.
NSAIDs (Ibuprofen): May reduce the antihypertensive effect.
Insulin/Antidiabetics: Atenolol may mask the symptoms of hypoglycemia (tachycardia).
Pregnancy & Lactation ▼
Pregnancy: Category D. Not recommended. It may cause fetal harm (IUGR, bradycardia). Use only if benefits outweigh risks.
Lactation: Both drugs are excreted in breast milk. Caution is advised, and breastfeeding is generally not recommended during therapy.
Clinical / Research Summary ▼
Synergistic Effect: The combination of Amlodipine (vasodilator) and Atenolol (beta-blocker) provides a dual mechanism of action. Amlodipine reduces systemic vascular resistance, while Atenolol prevents the reflex tachycardia often associated with vasodilators.
Hypertension Management: Clinical studies show that the combination is significantly more effective than either drug used as monotherapy for Stage 2 hypertension.
Anti-Ischemic Efficacy: In patients with chronic stable angina, this combination therapy increases exercise tolerance and reduces the frequency of anginal attacks.
Compliance: Single-pill combinations (SPC) improve patient adherence compared to taking multiple separate tablets.
Metabolic Considerations: Long-term use requires monitoring of blood glucose and lipid profiles, as beta-blockers can slightly impact insulin sensitivity.
Storage & Handling ▼
Store in a cool and dry place, below 30°C
Keep away from direct sunlight
Keep all medicines out of reach of children
Patient Counseling Points ▼
Adherence: Do not stop taking this medicine suddenly without consulting your doctor, as it may cause a rebound increase in blood pressure or chest pain.
Dizziness: Be careful when standing up from a sitting or lying position to avoid falls.
Diabetes: If you are diabetic, monitor your blood sugar closely as this medicine may hide signs of low blood sugar.
Ankle Swelling: If you notice significant swelling in your ankles, inform your healthcare provider.
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Amlocard-AT
Amtenal
Amloten
Camlodin Plus
Tenocheck
Amlopin AT
Angicard Plus
Atecard AM
Alopress AT
Amlon-AT
Tenocard AM
Lodipin AT
Amlosun AT
Modip AT
Rovasc AT
Amlo Plus
Cardipin AT
Normaten AM
Bizoran AT
Tenoretic AM
Tenoclor
Amlovas AT
Amlopres AT
Stamlo Beta
Amlong A
Amcard AT
Amlokind-AT
Amlodac AT
Atopina
Amten
Tenochek
Amlopres AT 50
Amlozen AT
Lodipin AT
Amlopin AT
Tenocil
Amlostat AT
Ate-Amlo
Amlo-Beta
Cordin AT Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.
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