Fosfomycin Sodium: Uses, Dosage, Side Effects | MedexInfo

Fosfomycin Sodium

Rx / Antibiotic

Generic NameFosfomycin Sodium

Therapeutic ClassPhosphonic Acid Derivative Antibiotic

RouteIV / Oral

Max / 24h12 g IV / 3 g Oral single dose (UTI)

PregnancyCategory B

Indications ▼

Uncomplicated urinary tract infections (UTIs) in adults and children

Complicated UTIs caused by susceptible Gram-positive and Gram-negative bacteria

Pyelonephritis

Prophylaxis of urinary tract infections in urological procedures

Other infections (off-label) caused by susceptible strains, including soft tissue infections and respiratory infections

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits bacterial cell wall synthesis by inactivating the enzyme UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), preventing peptidoglycan formation.

Pharmacokinetics: Rapidly absorbed orally (bioavailability ~37%); IV administration achieves high plasma levels. Widely distributed, excreted largely unchanged via urine. Half-life ~2–3 hours. Dose adjustment required in severe renal impairment.

Dosage & Administration ▼

Indication	Dose	Frequency
Uncomplicated UTI (adult, oral)	3 g	Single dose
Complicated UTI / IV therapy	4–6 g	Every 8–12 hours IV infusion
Severe infections (IV)	8–12 g	Divided doses q8–12h

Note: Administer IV slowly over 30–60 minutes. Oral granules should be dissolved in water before ingestion.

Side Effects ▼

Diarrhea, nausea, vomiting

Headache, dizziness

Injection site reactions (pain, phlebitis)

Rare: allergic reactions, hypokalemia

Contraindications ▼

Hypersensitivity to Fosfomycin or any excipients

Severe renal impairment without dose adjustment

Pediatrics under approved age for oral formulation

Drug Interaction ▼

Nephrotoxic drugs: may increase risk of kidney injury

Probenecid may reduce renal excretion of Fosfomycin

Live vaccines may have reduced efficacy when combined with antibiotics

Pregnancy & Lactation ▼

Category B: No evidence of risk in humans

Excreted in breast milk in small amounts; caution advised

Clinical / Research Summary ▼

Therapeutic Role: Broad-spectrum antibiotic effective against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains.

Clinical Effectiveness: Rapid bactericidal action in UTIs; high urinary concentrations achieved after single dose oral therapy.

Safety Profile: Generally well tolerated; gastrointestinal effects most common; rare hypersensitivity reactions reported.

Current Research: Focus on efficacy in multidrug-resistant urinary pathogens, alternative dosing regimens, and combination therapy studies.

Patient Counseling Points ▼

Complete full course even if symptoms improve

Dissolve oral granules completely before ingestion

Report severe diarrhea, rash, or allergic reactions

Maintain adequate hydration during therapy

Storage & Handling ▼

Store below 25°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Euticin® 3 gm Fosamin® 3 gm Fosfocin® 3 gm Fosfogen® 3 gm Fosfomax® 3 gm Monofocin® 3 gm Novefos® 3 gm Utifos® 3 gm Fosfomax® 4 gm IV

Global:

Monuril Fosfomycin

Medical Disclaimer: Educational purpose only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Antibiotics • Condition: Urinary Tract Infection • Condition: Pyelonephritis