Fluticasone Propionate Nasal Spray: Uses, Dosage, Side Effects | MedexInfo

Fluticasone Propionate (Nasal Spray)

Rx

Generic NameFluticasone Propionate

Therapeutic ClassIntranasal Corticosteroid

Max / 24h200 mcg/day

Common Dose100–200 mcg daily

PregnancyUse if benefit outweighs risk

Indications ▼

Seasonal allergic rhinitis (hay fever)

Perennial allergic rhinitis

Non-allergic rhinitis with nasal inflammation

Nasal congestion, sneezing, itching, and rhinorrhea

Prevention of allergic nasal symptoms before allergen exposure

Adjunct therapy in chronic rhinosinusitis

Post-operative nasal inflammation (ENT supervision)

Reduction of nasal mucosal edema and hyperreactivity

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits release of inflammatory mediators including histamine, cytokines, and leukotrienes in nasal mucosa, leading to reduced edema, mucus secretion, and nasal hyperresponsiveness.

Pharmacokinetics: Very low systemic bioavailability (<2%). Extensively metabolized in liver via CYP3A4. Minimal systemic corticosteroid effect at recommended dose.

Dosage & Administration ▼

Age Group	Dosage	Frequency
Adults & ≥12 years	2 sprays in each nostril (50 mcg/spray)	Once daily (200 mcg)
Maintenance	1 spray each nostril	Once daily (100 mcg)
Children 4–11 years	1 spray each nostril	Once daily (100 mcg)

Onset: Symptom relief begins within 6–12 hours; maximum effect may take 2–3 days.

Side Effects ▼

Nasal irritation or dryness

Epistaxis (nosebleed)

Sore throat

Headache

Rare: nasal septum perforation with prolonged misuse

Contraindications ▼

Hypersensitivity to fluticasone

Untreated nasal infections

Recent nasal surgery or trauma (until healed)

Drug Interaction ▼

Strong CYP3A4 inhibitors (ritonavir, ketoconazole) may increase systemic steroid exposure

Concurrent corticosteroids increase risk of adrenal suppression

Pregnancy & Lactation ▼

Use lowest effective dose during pregnancy

Preferred intranasal steroid when benefit outweighs risk

Compatible with breastfeeding at therapeutic dose

Clinical / Research Summary ▼

Clinical Role: First-line therapy for moderate to severe allergic rhinitis.

Effectiveness: Superior to oral antihistamines for nasal congestion.

Safety: Very low systemic absorption when used correctly.

Research Focus: Long-term safety and symptom prevention strategies.

Patient Counseling Points ▼

Use regularly for best effect, not for instant relief

Shake bottle before use

Aim spray away from nasal septum

Do not exceed recommended daily dose

Storage & Handling ▼

Store below 30°C

Do not freeze

Keep cap tightly closed

Brand Names (Bangladesh & Global) ▼

Bangladesh:

F-Pro® 50 mcg/spray Flixonat® 50 mcg/spray Flonaspray® 50 mcg/spray Flonaspray Max® 93 mcg/spray Fluticon® 50 mcg/spray Flutispray® 50 mcg/spray Fluvate® 50 mcg/spray Fluvent® 50 mcg/spray Lutisone® 50 mcg/spray Nasoflu® 50 mcg/spray Perinase® 50 mcg/spray

Global:

Flonase Flixonase

Medical Disclaimer: Educational purpose only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Intranasal Corticosteroids • Condition: Allergic Rhinitis • Condition: Sinusitis