Generic Name: Lubiprostone
Therapeutic Class: Chloride Channel Activator (Laxative)
Indications
Indicated for treatment of chronic idiopathic constipation (CIC) in adults, opioid‑induced constipation (OIC) in adults with chronic non‑cancer pain, and irritable bowel syndrome with constipation (IBS‑C) in adult women.:contentReference[oaicite:1]{index=1}
Presentation
Capsule: Available as 8 mcg and 24 mcg oral capsules containing Lubiprostone.:contentReference[oaicite:2]{index=2}
Description
Lubiprostone works locally in the gut by activating chloride channels (ClC‑2), increasing intestinal fluid secretion and motility, which helps soften stools and relieve constipation without significant systemic absorption.:contentReference[oaicite:3]{index=3}
Dosage & Administration
Adults with CIC or OIC: 24 mcg orally twice daily with food and water.
Adults with IBS‑C: 8 mcg orally twice daily with food and water.
Take capsules with food to reduce nausea.:contentReference[oaicite:4]{index=4}
Adults with IBS‑C: 8 mcg orally twice daily with food and water.
Take capsules with food to reduce nausea.:contentReference[oaicite:4]{index=4}
Side Effects
Common side effects include nausea, vomiting, diarrhea, loose stools, dry mouth, stomach discomfort, headache, and dizziness.:contentReference[oaicite:5]{index=5}
Pregnancy & Lactation
Category C. Use only if clearly needed after consulting a clinician, as safety data in pregnancy and lactation are limited.:contentReference[oaicite:6]{index=6}
Precautions & Interactions
Avoid use in patients with known or suspected mechanical gastrointestinal obstruction. Use caution in cases of severe diarrhea and in patients with hepatic impairment.:contentReference[oaicite:7]{index=7}
Overdose
Overdose symptoms may include exaggerated GI effects such as severe diarrhea, nausea, vomiting, and abdominal pain. Seek medical attention if suspected.:contentReference[oaicite:8]{index=8}
Storage
Store in a cool, dry place below 25–30 °C, protected from light and moisture, and keep out of reach of children.:contentReference[oaicite:9]{index=9}
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