Tropicamide + Phenylephrine Hydrochloride | MedexInfo

Tropicamide + Phenylephrine Hydrochloride

Rx

Generic NameTropicamide + Phenylephrine HCl

Therapeutic ClassMydriatic / Cycloplegic

Common StrengthTropicamide 0.5–1%, Phenylephrine 2–10%

Max / 24hAs directed by ophthalmologist; typically single-use per exam

PregnancyUse if benefit outweighs risk

Indications ▼

Pupil dilation for fundus examination

Preoperative mydriasis for ocular surgery

Mechanism & Pharmacokinetics ▼

Mechanism: Tropicamide is a muscarinic antagonist that causes cycloplegia and pupil dilation. Phenylephrine is an α1-adrenergic agonist that stimulates the dilator pupillae muscle, producing mydriasis. Combined, they achieve rapid and sustained pupil dilation for examination.

Pharmacokinetics: Topically applied; minimal systemic absorption. Onset 15–30 minutes; duration 4–6 hours. Metabolized minimally; excreted mainly via urine.

Dosage & Administration ▼

Indication	Dose	Frequency
Fundus examination / preoperative dilation	1–2 drops in affected eye(s)	Once; may repeat in 10–15 minutes if needed

Note: Use the lowest effective dose; avoid contact with eyelids to reduce systemic absorption.

Side Effects ▼

Transient stinging or burning in eye

Photophobia, blurred vision

Increased intraocular pressure in susceptible patients

Rare: systemic hypertension, tachycardia, headache

Allergic reaction (rare)

Contraindications ▼

Hypersensitivity to tropicamide, phenylephrine, or other components

Patients with narrow-angle glaucoma (risk of acute attack)

Severe cardiovascular disease (for phenylephrine component)

Drug Interaction ▼

Other mydriatics or sympathomimetics: additive systemic effects

Monoamine oxidase inhibitors (MAOIs): may enhance hypertensive response

Pregnancy & Lactation ▼

Limited human data; use only if clinically necessary

Unknown excretion in breast milk; caution advised

Clinical / Research Summary ▼

Clinical Role: Provides rapid and effective pupil dilation for ocular examination and surgery.

Advantage: Combines cycloplegia and mydriasis for reliable examination.

Limitation: Short duration; systemic absorption can cause cardiovascular effects in sensitive patients.

Monitoring: Watch for ocular discomfort, rise in intraocular pressure, systemic cardiovascular signs.

Patient Counseling Points ▼

Inform patient about temporary blurred vision and photophobia

Avoid driving or operating machinery until vision clears

Use a tissue to blot excess drops to prevent systemic absorption

Report severe eye pain, redness, or cardiovascular symptoms

Storage & Handling ▼

Store at 2–8°C

Protect from light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Dilate Plus® 0.8%+5% Mydrimide Plus® 0.8%+5% Ocutrop Plus® 0.8%+5% Trocane® 0.8%+5% Trophen® 0.8%+5% Tropidil Plus® 0.8%+5% Tropigen Plus® 0.8%+5% Vasotrop® 0.8%+5%

Global:

Mydfrin®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Mydriatics • Condition: Ocular Examination