Roxithromycin: Uses, Dosage, Side Effects & Brands | MedexInfo

Roxithromycin

Rx Only

Generic NameRoxithromycin

Therapeutic ClassMacrolide Antibiotic

Common Dose150 mg twice daily or 300 mg once daily

Max / 24h300 mg

PregnancyCategory B

Indications ▼

Upper respiratory tract infections (pharyngitis, sinusitis, tonsillitis)

Lower respiratory tract infections (bronchitis, pneumonia)

Skin and soft tissue infections

Urogenital infections caused by susceptible organisms

Mechanism & Pharmacokinetics ▼

Mechanism: Binds to 50S ribosomal subunit of bacteria, inhibiting protein synthesis and preventing bacterial growth (bacteriostatic).

Pharmacokinetics: Well absorbed orally; peak plasma concentration in 2 hours; highly protein bound; metabolized in liver; excreted via bile and urine; half-life ~12 hours.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	150 mg twice daily or 300 mg once daily	300 mg
Elderly	Same as adults; monitor liver function if needed	300 mg
Children (>40 kg)	150 mg twice daily	300 mg
Children (<40 kg)	5–8 mg/kg/day in 2 divided doses	300 mg

Note: Take at least 15 minutes before meals for better absorption. Complete the full prescribed course.

Side Effects ▼

Common: Nausea, vomiting, abdominal pain, diarrhea

Occasional: Headache, dizziness, rash

Rare: Hepatotoxicity, allergic reactions, QT prolongation

Contraindications ▼

Hypersensitivity to macrolide antibiotics

Severe hepatic impairment

History of QT prolongation

Drug Interaction ▼

May increase effects of warfarin

Increased QT risk with antiarrhythmics

Caution with CYP3A4 substrates

Pregnancy & Lactation ▼

Category B; use only if clearly needed

Small amounts excreted in breast milk; monitor infant

Clinical / Research Summary ▼

Effective against common respiratory pathogens including Streptococcus and Haemophilus species

Good tissue penetration and prolonged half-life allows convenient dosing

Alternative option in penicillin-allergic patients

Patient Counseling Points ▼

Take before meals as prescribed

Complete full antibiotic course

Report severe diarrhea or allergic reactions immediately

Storage & Handling ▼

Store below 25°C; protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Pedilid® 150 mg A-Rox® 150 mg A-Rox® 300 mg Pedilid® 300 mg Rolid® 300 mg Rotomycin® 300 mg Roxcin® 150 mg Roxcin® 300 mg Ryth® 150 mg Ryth® 300 mg A-Rox® 50 mg/5 ml Pedilid® 50 mg/5 ml Rolid® 50 mg/5 ml Roxcin® 50 mg/5 ml Ryth® 50 mg/5 ml

Global:

Rulid® Roxithromycin (Generic)

Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice.

Reference Hubs:

• Drug Class: Macrolides • Condition: Respiratory Infections • Clinical Evidence & Studies