Rivaroxaban: Uses, Dosage, Side Effects & Brands | MedexInfo

Rivaroxaban

Rx Only

Generic NameRivaroxaban

Therapeutic ClassFactor Xa Inhibitor (DOAC)

Common Dose10–20 mg once daily

Max / 24h20 mg

PregnancyNot Recommended

Indications ▼

Prevention of stroke and systemic embolism in non-valvular atrial fibrillation

Treatment of deep vein thrombosis (DVT)

Treatment of pulmonary embolism (PE)

Prevention of recurrent DVT and PE

Thromboprophylaxis after hip or knee replacement surgery

Mechanism & Pharmacokinetics ▼

Mechanism: Selectively inhibits Factor Xa, blocking thrombin generation and thrombus formation.

Pharmacokinetics: Rapid absorption; peak concentration in 2–4 hours; high protein binding (~95%); metabolized via CYP3A4 and CYP2J2; elimination via renal and fecal pathways; half-life 5–13 hours.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Non-valvular AF	20 mg once daily with evening meal	20 mg
DVT / PE Treatment	15 mg twice daily for 21 days, then 20 mg once daily	30 mg (initial phase)
Post-Orthopedic Surgery	10 mg once daily	10 mg
Renal Impairment	Dose adjustment required based on CrCl	20 mg

Note: Take with food for doses ≥15 mg. Do not discontinue abruptly without medical advice.

Side Effects ▼

Common: Bleeding, anemia, bruising

Occasional: Nausea, dizziness, headache

Serious: Major bleeding, intracranial hemorrhage

Contraindications ▼

Active pathological bleeding

Severe hepatic disease with coagulopathy

Hypersensitivity to rivaroxaban

Drug Interaction ▼

Strong CYP3A4 and P-gp inhibitors (e.g., ketoconazole) increase bleeding risk

Strong CYP3A4 inducers (e.g., rifampicin) reduce efficacy

Concomitant anticoagulants or antiplatelets increase bleeding risk

Pregnancy & Lactation ▼

Not recommended during pregnancy due to bleeding risk

Excretion in breast milk unknown; avoid during lactation

Clinical / Research Summary ▼

Proven efficacy in stroke prevention in atrial fibrillation (ROCKET-AF trial)

Comparable or superior to warfarin with fixed dosing and no routine INR monitoring

Reduced intracranial bleeding compared to vitamin K antagonists

Widely used DOAC with predictable pharmacokinetics

Patient Counseling Points ▼

Take with food (for 15 mg and 20 mg doses)

Do not skip doses or stop abruptly

Report signs of bleeding immediately

Inform doctors before surgery or dental procedures

Storage & Handling ▼

Store below 30°C

Keep away from moisture and heat

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Kinexa® 2.5 mg Kinexa® 10 mg Kinexa® 15 mg Kinexa® 20 mg Oxaban® 10 mg Rafter® 2.5 mg Rafter® 10 mg Rafter® 15 mg Rafter® 20 mg Rivaban® 2.5 mg Rivaban® 10 mg Rivaban® 20 mg Rivadel® 2.5 mg Rivadel® 10 mg Rivadel® 20 mg Rivarox® 2.5 mg Rivarox® 10 mg Rivarox® 15 mg Rivarox® 20 mg RivaXa® 2.5 mg RivaXa® 10 mg Rivosis® 10 mg Rixoban® 2.5 mg Rixoban® 10 mg Rivanex® 2.5 mg Rivanex® 10 mg Roxolyte® 10 mg Varox® 2.5 mg Varox® 10 mg Xarelta® 2.5 mg Xarelta® 10 mg Xarelta® 15 mg Xarelta® 20 mg Global:

Xarelto® Rivaroxaban (Generic)

Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice.

Reference Hubs:

• Drug Class: Anticoagulants • Condition: Atrial Fibrillation • Condition: DVT / PE • Clinical Evidence & Trials

Rivaroxaban: Uses, Dosage, Side Effects & Brands | MedexInfo Reviewed by Rasel Bapy on 10 May Rating: 5