Retapamulin: Uses, Dosage, Side Effects & Brands | MedexInfo

Retapamulin

Rx

Generic NameRetapamulin

Therapeutic ClassTopical Antibiotic (Pleuromutilin)

Dosage Form1% Topical Ointment

RouteTopical (Skin)

PregnancyUse if benefit outweighs risk

Indications ▼

Impetigo: Treatment of impetigo caused by Staphylococcus aureus or Streptococcus pyogenes.

Secondary Skin Infections: Localized superficial skin infections due to susceptible Gram-positive organisms.

Suitable for mild to moderate infections with limited skin involvement.

Intended for short-term topical use only.

Mechanism & Pharmacokinetics ▼

Mechanism: Retapamulin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit at a unique site, blocking peptidyl transferase activity and preventing bacterial growth.

Pharmacokinetics: Minimal systemic absorption after topical application on intact skin. Absorbed drug is metabolized in the liver, mainly via CYP3A4, and eliminated primarily through feces.

Dosage & Administration ▼

Indication	Dose	Frequency
Impetigo (Adults & Children ≥9 months)	Apply thin layer to affected area	Twice daily for 5 days

Note: Area may be covered with sterile gauze if needed. Avoid contact with eyes, mouth, and mucous membranes.

Side Effects ▼

Application site irritation

Pruritus or erythema

Burning or stinging sensation

Contact dermatitis (rare)

Contraindications ▼

Known hypersensitivity to retapamulin or formulation components

Use on mucosal surfaces

Drug Interaction ▼

Strong CYP3A4 inhibitors (e.g., ketoconazole) may increase systemic exposure

Risk is minimal due to low systemic absorption

Avoid concurrent use with other topical agents on same site unless advised

Pregnancy & Lactation ▼

Limited human pregnancy data; use only if clearly needed

Unknown whether excreted in breast milk; caution advised during lactation

Clinical / Research Summary ▼

Clinical Role: Effective topical option for uncomplicated impetigo.

Advantage: Unique mechanism reduces cross-resistance with other topical antibiotics.

Limitation: Not suitable for extensive skin infections or systemic use.

Monitoring: Clinical response and signs of local irritation.

Patient Counseling Points ▼

Clean and dry affected area before application

Use for full prescribed duration even if symptoms improve

Avoid eyes, mouth, and inside nose

Report worsening redness or irritation

Storage & Handling ▼

Store below 25°C

Do not freeze

Keep tube tightly closed

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Altabax (limited availability)

Global:

Altabax®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Topical Antibiotic • Condition: Impetigo