Remdesivir: Uses, Dosage, Side Effects & Brands | MedexInfo

Remdesivir

Rx Only

Generic NameRemdesivir

Therapeutic ClassAntiviral

Common Dose200 mg IV loading, then 100 mg IV daily

Max / 24h200 mg (loading), 100 mg daily

PregnancyCategory B

Indications ▼

Hospitalized COVID-19 patients requiring supplemental oxygen

Severe COVID-19 infection to reduce disease progression

Use as part of clinical protocols or emergency use authorization guidelines

Mechanism & Pharmacokinetics ▼

Mechanism: Remdesivir is a prodrug converted to an adenosine nucleotide analog that inhibits viral RNA-dependent RNA polymerase, causing premature termination of viral RNA replication.

Pharmacokinetics: IV administration; distributes widely in tissues; metabolized to active nucleoside triphosphate; elimination primarily renal; half-life ~1 hour for parent drug, ~25 hours for active metabolite.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	200 mg IV loading on day 1, then 100 mg IV daily for 5–10 days	200 mg (loading), 100 mg daily
Children ≥12 years & ≥40 kg	Same as adults	200 mg (loading), 100 mg daily
Renal Impairment (eGFR <30 mL/min)	Use with caution; monitor renal function	As per physician
Hepatic Impairment	Use with caution; monitor liver enzymes	As per physician

Note: Administer as IV infusion over 30–120 minutes. Do not mix with other medications. Monitor liver and kidney function before and during therapy.

Side Effects ▼

Common: Nausea, headache, elevated liver enzymes

Occasional: Hypotension, rash, infusion site reactions

Rare: Severe hypersensitivity, renal toxicity, bradycardia

Contraindications ▼

Hypersensitivity to Remdesivir or any component

Severe renal impairment (eGFR <30 mL/min) unless benefit outweighs risk

Severe hepatic impairment

Drug Interaction ▼

Co-administration with nephrotoxic drugs may increase renal toxicity

Concurrent hydroxychloroquine or chloroquine not recommended; may reduce antiviral efficacy

Pregnancy & Lactation ▼

Pregnancy Category B; use only if clearly needed

Excreted in breast milk in unknown amounts; monitor infant if used

Clinical / Research Summary ▼

Shown to reduce recovery time in hospitalized COVID-19 patients

Effective against SARS-CoV-2 by inhibiting viral RNA polymerase

Used under Emergency Use Authorization in several countries

Safety profile generally acceptable; monitor liver and kidney function

Patient Counseling Points ▼

Administer exactly as IV infusion prescribed

Do not skip doses; complete full course

Report nausea, rash, or unusual symptoms immediately

Monitor kidney and liver function before and during therapy

Storage & Handling ▼

Store at 2–8°C; protect from light

Do not freeze; use reconstituted solution immediately

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Remivir® 5 mg/ml Bemsivir® 5 mg/ml Dilavir® 5 mg/ml Ninavir® 5 mg/ml Pandovir® 5 mg/ml Ramdivir® 5 mg/ml Remcor® 5 mg/ml Remdevir® 5 mg/ml Remdigen® 5 mg/ml Remdinil® 5 mg/ml Remicov® 5 mg/ml

Global:

Veklury® Remdesivir (Generic)

Medical Disclaimer: This information is for educational purposes only. Consult a qualified healthcare professional for diagnosis and treatment.

Reference Hubs:

• Drug Class: Antivirals • Condition: COVID-19 • Pathway: RNA Polymerase Inhibition • Clinical Evidence & Trials