Procyclidine Hydrochloride: Uses,Dosage,Side Effects | MedexInfo

Procyclidine Hydrochloride

Rx Only

Generic NameProcyclidine Hydrochloride

Therapeutic ClassAnticholinergic / Anti-Parkinsonian

Common Dose2.5–10 mg daily in divided doses

Max / 24h15 mg

PregnancyCategory C

Indications ▼

Parkinson's disease – to control tremor and rigidity

Drug-induced extrapyramidal symptoms (EPS)

Adjunct in acute dystonic reactions

Mechanism & Pharmacokinetics ▼

Mechanism: Anticholinergic that blocks central muscarinic receptors, restoring balance between acetylcholine and dopamine in the basal ganglia.

Pharmacokinetics: Well absorbed orally; metabolized in the liver; excreted via urine; half-life ~8–12 hours; crosses the blood-brain barrier.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	2.5–5 mg orally 2–3 times daily, adjust per response	15 mg
Elderly	Start at 2.5 mg once daily; titrate cautiously	10 mg
Children ≥6 years	0.05–0.1 mg/kg/day in divided doses	15 mg or as per clinician

Note: Administer with food to reduce GI upset. Adjust dose in renal or hepatic impairment.

Side Effects ▼

Dry mouth, blurred vision, constipation, urinary retention

Drowsiness, confusion, dizziness

Rare: tachycardia, hypotension, hallucinations

Contraindications ▼

Glaucoma (narrow-angle)

Myasthenia gravis

Severe gastrointestinal obstruction or urinary retention

Hypersensitivity to procyclidine

Drug Interaction ▼

Other anticholinergics may potentiate side effects

Concurrent antihistamines or tricyclic antidepressants increase anticholinergic burden

May reduce efficacy of drugs requiring cholinergic activity

Pregnancy & Lactation ▼

Use only if benefits outweigh risks; limited human data

Excreted in breast milk in small amounts; monitor infant for anticholinergic effects

Clinical / Research Summary ▼

Effective in controlling tremor, rigidity, and EPS in Parkinsonism

Rapid symptomatic relief in drug-induced dystonia

Supported by clinical trials and expert guidelines

Patient Counseling Points ▼

Take exactly as prescribed; do not stop abruptly

Avoid driving or operating machinery until alertness is confirmed

Report signs of urinary retention, severe constipation, or hallucinations

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Cyclid® 5 mg Tablet Cyclid® 10 mg/2 ml Injection Extranil® 5 mg Tablet Extranil® 10 mg/2 ml Injection Kdrin® 5 mg Tablet Kdrin® 10 mg/2 ml Injection Perkinil® 5 mg Tablet Perkinil® 10 mg/2 ml Injection Rocy® 5 mg Tablet

Global:

Kemadrin® Procyclidine Hydrochloride

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Anticholinergics / Anti-Parkinsonian Agents • Condition: Parkinson's Disease • Pathway: Muscarinic Receptor Blockade • Clinical Evidence & Trials