Pregabalin: Uses, Dosage, Side Effects & Brands | MedexInfo

Pregabalin

Rx Only

Generic NamePregabalin

Therapeutic ClassAnticonvulsant / Neuropathic Pain Agent

Common Dose75–300 mg daily in divided doses

Max / 24h600 mg

PregnancyCategory C

Indications ▼

Neuropathic pain (diabetic peripheral neuropathy, postherpetic neuralgia)

Adjunctive therapy for partial-onset seizures in adults

Fibromyalgia

Mechanism & Pharmacokinetics ▼

Mechanism: Binds to the α2δ subunit of voltage-gated calcium channels in the CNS, reducing neurotransmitter release and neuronal excitability.

Pharmacokinetics: Rapidly absorbed orally; bioavailability >90%; not significantly metabolized; excreted primarily unchanged in urine; half-life ~6.3 hours.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	75–150 mg twice daily; may increase to 300 mg/day based on response	600 mg
Elderly	Start at lower end (75 mg/day); adjust based on renal function	600 mg
Children ≥1 month	Dose individualized per weight and indication; follow specialist guidance	Follow pediatric guidelines

Note: Adjust dose in renal impairment. Can be taken with or without food. Swallow capsules whole.

Side Effects ▼

Dizziness, somnolence, blurred vision

Weight gain, peripheral edema

Dry mouth, constipation

Rare: angioedema, myopathy, or mood changes

Contraindications ▼

Hypersensitivity to pregabalin or any component

Caution in patients with renal impairment; dose adjustment required

Monitor for CNS depression when combined with other sedatives

Drug Interaction ▼

May potentiate CNS depressants (e.g., alcohol, opioids, benzodiazepines)

No significant CYP-mediated interactions

Concurrent ACE inhibitors may increase risk of peripheral edema

Pregnancy & Lactation ▼

Use only if potential benefit justifies risk; limited human data

Excreted in breast milk in small amounts; monitor infant for CNS effects

Clinical / Research Summary ▼

Effective in neuropathic pain management and seizure adjunct therapy

Well-tolerated in most adults; improves quality of life in chronic neuropathic conditions

Extensively studied in randomized clinical trials

Patient Counseling Points ▼

Take exactly as prescribed; do not abruptly discontinue

Avoid driving or operating machinery until you know how it affects you

Report swelling, unusual bruising, or mood changes to your doctor

Storage & Handling ▼

Store at 20–25°C (68–77°F)

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Pregaba® 25 mg Capsule Algaba® 50 mg Capsule Algaba® 75 mg Capsule Algaba® 150 mg Capsule Asibalin® 25 mg Capsule Asibalin® 50 mg Capsule Asibalin® 75 mg Capsule Broklin® 50 mg Capsule Broklin® 75 mg Capsule Broklin CR® 82.5 mg Tablet Broklin CR® 165 mg Tablet Pregaba® 50 mg Capsule Pregaba® 75 mg Capsule Pregaba ER® 82.5 mg Tablet Pregaben® 50 mg Capsule Pregaben® 75 mg Capsule Pregaben CR® 165 mg Tablet Nervalin® 25 mg Capsule Nervalin CR® 330 mg Tablet SB‑Gabalin® 50 mg Capsule

Global:

Lyrica® Pregabalin

Medical Disclaimer: This information is for educational purposes only. Consult a healthcare provider for professional guidance.

Reference Hubs:

• Drug Class: Anticonvulsants / Neuropathic Pain Agents • Condition: Neuropathic Pain • Pathway: Calcium Channel α2δ Subunit Modulation • Clinical Evidence & Trials