Polymyxin B Sulfate
Rx Only
Generic NamePolymyxin B Sulfate
Therapeutic ClassPolymyxin Antibiotic
Common Dose15,000–25,000 units/kg/day
Max / 24h2.5 million units
PregnancyCategory C
Indications ▼
Severe infections caused by susceptible Gram-negative bacteria
Bacteremia and septicemia
Urinary tract infections
Meningitis (intrathecal use in specific cases)
Topical and ophthalmic infections
Mechanism & Pharmacokinetics ▼
Mechanism: Binds to bacterial cell membrane phospholipids, increasing membrane permeability and causing leakage of intracellular components leading to bacterial cell death.
Pharmacokinetics: Poor oral absorption; administered parenterally or topically. Distributed mainly in extracellular fluid. Eliminated primarily via kidneys. Half-life approximately 6–12 hours depending on renal function.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults (IV) | 15,000–25,000 units/kg/day divided every 12 hours | 2.5 million units |
| Children | 15,000–25,000 units/kg/day divided doses | 2.5 million units |
| Intrathecal (Meningitis) | 5,000–10,000 units daily as directed | As prescribed |
| Ophthalmic | 1–2 drops every 3–4 hours | As directed |
Note: Adjust dose in renal impairment. Monitor renal function and neurological status during therapy.
Side Effects ▼
Common: Injection site pain, mild rash
Occasional: Nephrotoxicity, dizziness
Rare: Neurotoxicity, respiratory muscle paralysis, paresthesia
Contraindications ▼
Hypersensitivity to polymyxins
Use with caution in patients with renal impairment
Drug Interaction ▼
Concurrent nephrotoxic drugs (aminoglycosides, vancomycin) increase renal toxicity risk
Neuromuscular blocking agents: enhanced neuromuscular blockade
Pregnancy & Lactation ▼
Category C; use only if benefit outweighs risk
Safety in breastfeeding not fully established
Clinical / Research Summary ▼
Effective against multidrug-resistant Gram-negative organisms.
Reserved for serious infections due to toxicity risk.
Requires close monitoring of renal and neurological function.
Patient Counseling Points ▼
Report decreased urine output or numbness immediately.
Complete full course as prescribed.
Avoid self-medication with other antibiotics.
Storage & Handling ▼
Store at 20–25°C; protect from light
Reconstituted solution should be used promptly or as directed
Brand Names (Bangladesh & Global) ▼
Lipoxin B® 5 lac unit Injection
Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider.
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