Valsartan + Hydrochlorothiazide: Uses, Dosage, Side Effects | MedexInfo

Valsartan + Hydrochlorothiazide

Rx

Generic NameValsartan + Hydrochlorothiazide

Therapeutic ClassARB + Thiazide Diuretic

Max / 24hValsartan 320 mg + HCTZ 25 mg

Common Dose80/12.5 mg to 160/25 mg once daily

PregnancyContraindicated (Category D)

Indications ▼

Essential hypertension in adults

Patients not adequately controlled with monotherapy

Combination therapy for cardiovascular risk reduction

Mechanism & Pharmacokinetics ▼

Mechanism: Valsartan blocks angiotensin II receptors, reducing vasoconstriction and aldosterone secretion. Hydrochlorothiazide inhibits sodium reabsorption in the distal tubules, promoting diuresis and lowering blood pressure.

Pharmacokinetics: Valsartan: Oral bioavailability ~25%, peak 2–4 h, mainly excreted in feces; half-life 6 h. HCTZ: Rapidly absorbed, peak 1–5 h, excreted renally; half-life 6–15 h.

Dosage & Administration ▼

Condition	Recommended Dose	Frequency
Hypertension	80/12.5 mg	Once daily; may increase to 160/25 mg if needed
Resistant hypertension	160/25 mg	Once daily

Note: Take with or without food. Monitor blood pressure, kidney function, and electrolytes regularly.

Side Effects ▼

Dizziness, headache

Fatigue

Hyperkalemia, hypotension

Gastrointestinal upset

Rare: Angioedema, renal impairment

Contraindications ▼

Hypersensitivity to valsartan, HCTZ, or sulfonamides

Pregnancy (especially 2nd & 3rd trimester)

Severe renal or hepatic impairment

Anuria or electrolyte imbalance

Drug Interaction ▼

Other antihypertensives: additive hypotension

Potassium supplements or potassium-sparing diuretics: risk of hyperkalemia

NSAIDs: may reduce antihypertensive effect and increase renal risk

Diabetes medications: monitor blood glucose

Pregnancy & Lactation ▼

Contraindicated in pregnancy (Category D)

Not recommended during breastfeeding; consult physician

Clinical / Research Summary ▼

Therapeutic Role: Effective combination for controlling blood pressure in patients inadequately managed by monotherapy.

Clinical Effectiveness: Reduces systolic and diastolic blood pressure, lowers cardiovascular risk.

Safety Profile: Well tolerated; monitor electrolytes, renal function, and blood pressure.

Current Research: Evaluating long-term cardiovascular and renal outcomes in hypertensive patients.

Patient Counseling Points ▼

Take at the same time daily, with or without food

Do not stop medication abruptly

Monitor blood pressure, kidney function, and electrolytes regularly

Report dizziness, swelling, or unusual fatigue to your physician

Storage & Handling ▼

Store below 30°C in a dry place

Protect from light and moisture

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh (Local Brands):

Valsartil Plus Co-Diovan Valsacor H

Global / International Brands:

Exforge H Co-Diovan

Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.

Reference Hubs:

• Drug Class: Angiotensin II Receptor Blockers • Conditions: Hypertension • Drug Class: Thiazide Diuretics