Telmisartan: Uses, Dosage, Side Effects & Brands | MedexInfo
Telmisartan
Rx
Generic NameTelmisartan
Therapeutic ClassARB
Max / 24h80 mg
Common Dose20–80 mg orally once daily
PregnancyContraindicated in 2nd and 3rd trimester
Indications ▼
Essential hypertension in adults
Reduction of cardiovascular risk (stroke, myocardial infarction, all-cause mortality) in patients ≥55 years with high-risk factors
Heart failure with preserved ejection fraction (HFpEF)
Diabetic nephropathy and proteinuria in type 2 diabetes
Patients intolerant to ACE inhibitors
Mechanism & Pharmacokinetics ▼
Mechanism: Selective angiotensin II type 1 receptor antagonist; reduces vasoconstriction and aldosterone secretion, lowering blood pressure and decreasing cardiovascular workload.
Pharmacokinetics: Rapid oral absorption, peak plasma 0.5–1.5 h; highly protein-bound (~99.5%), metabolized minimally in liver; half-life ~24 h, primarily excreted via feces and urine unchanged.
Dosage & Administration ▼
| Condition | Recommended Dose | Frequency |
|---|---|---|
| Essential Hypertension | 40 mg | Once daily; may increase to 80 mg |
| Cardiovascular Risk Reduction | 80 mg | Once daily |
| Diabetic Nephropathy / Proteinuria | 40–80 mg | Once daily |
| Elderly / mild hepatic impairment | 20 mg | Once daily, adjust based on response |
Note: Can be taken with or without food; monitor BP, kidney function, and electrolytes during therapy.
Side Effects ▼
Dizziness, headache
Fatigue, nausea, diarrhea
Hypotension, syncope
Hyperkalemia
Rare: Angioedema, hepatic enzyme elevation, renal impairment
Contraindications ▼
Hypersensitivity to Telmisartan
Pregnancy (2nd and 3rd trimester)
Severe hepatic impairment
Severe hypotension or cardiogenic shock
Drug Interaction ▼
Potassium-sparing diuretics or ACE inhibitors: risk of hyperkalemia
NSAIDs: may reduce antihypertensive effect and increase renal risk
Other antihypertensives: additive BP lowering
Lithium: increased lithium levels
Pregnancy & Lactation ▼
Contraindicated in 2nd and 3rd trimester
Excretion in breast milk unknown; avoid or monitor infant
Clinical / Research Summary ▼
Therapeutic Role: Effective ARB for lowering blood pressure and reducing cardiovascular risk; protects kidneys in diabetes and elderly patients.
Clinical Effectiveness: Reduces systolic and diastolic BP; improves cardiovascular outcomes in high-risk hypertensive patients.
Safety Profile: Generally well tolerated; monitor BP, kidney function, and electrolytes regularly.
Current Research: Focus on long-term cardiovascular and renal protection, combination therapy, and optimal dosing strategies.
Patient Counseling Points ▼
Take at the same time daily
Maintain adequate hydration
Report dizziness, fainting, or swelling
Do not discontinue suddenly
Regularly monitor blood pressure and kidney function
Storage & Handling ▼
Store below 30°C, protect from moisture and light
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Telmipres®
Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.
Telmisartan
Rx
Generic NameTelmisartan
Therapeutic ClassARB
Max / 24h80 mg
Common Dose20–80 mg orally once daily
PregnancyContraindicated in 2nd and 3rd trimester
Indications ▼
Essential hypertension in adults
Reduction of cardiovascular risk (stroke, myocardial infarction, all-cause mortality) in patients ≥55 years with high-risk factors
Heart failure with preserved ejection fraction (HFpEF)
Diabetic nephropathy and proteinuria in type 2 diabetes
Patients intolerant to ACE inhibitors
Mechanism & Pharmacokinetics ▼
Mechanism: Selective angiotensin II type 1 receptor antagonist; reduces vasoconstriction and aldosterone secretion, lowering blood pressure and decreasing cardiovascular workload.
Pharmacokinetics: Rapid oral absorption, peak plasma 0.5–1.5 h; highly protein-bound (~99.5%), metabolized minimally in liver; half-life ~24 h, primarily excreted via feces and urine unchanged.
Dosage & Administration ▼
| Condition | Recommended Dose | Frequency |
|---|---|---|
| Essential Hypertension | 40 mg | Once daily; may increase to 80 mg |
| Cardiovascular Risk Reduction | 80 mg | Once daily |
| Diabetic Nephropathy / Proteinuria | 40–80 mg | Once daily |
| Elderly / mild hepatic impairment | 20 mg | Once daily, adjust based on response |
Note: Can be taken with or without food; monitor BP, kidney function, and electrolytes during therapy.
Side Effects ▼
Dizziness, headache
Fatigue, nausea, diarrhea
Hypotension, syncope
Hyperkalemia
Rare: Angioedema, hepatic enzyme elevation, renal impairment
Contraindications ▼
Hypersensitivity to Telmisartan
Pregnancy (2nd and 3rd trimester)
Severe hepatic impairment
Severe hypotension or cardiogenic shock
Drug Interaction ▼
Potassium-sparing diuretics or ACE inhibitors: risk of hyperkalemia
NSAIDs: may reduce antihypertensive effect and increase renal risk
Other antihypertensives: additive BP lowering
Lithium: increased lithium levels
Pregnancy & Lactation ▼
Contraindicated in 2nd and 3rd trimester
Excretion in breast milk unknown; avoid or monitor infant
Clinical / Research Summary ▼
Therapeutic Role: Effective ARB for lowering blood pressure and reducing cardiovascular risk; protects kidneys in diabetes and elderly patients.
Clinical Effectiveness: Reduces systolic and diastolic BP; improves cardiovascular outcomes in high-risk hypertensive patients.
Safety Profile: Generally well tolerated; monitor BP, kidney function, and electrolytes regularly.
Current Research: Focus on long-term cardiovascular and renal protection, combination therapy, and optimal dosing strategies.
Patient Counseling Points ▼
Take at the same time daily
Maintain adequate hydration
Report dizziness, fainting, or swelling
Do not discontinue suddenly
Regularly monitor blood pressure and kidney function
Storage & Handling ▼
Store below 30°C, protect from moisture and light
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Medical Disclaimer: This information is intended for educational purposes only and must not replace professional medical advice.
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