Baricitinib: Uses, Dosage, Side Effects & Brands | MedexInfo
Baricitinib
Rx Only
Therapeutic ClassJAK Inhibitor
Common Dose2–4 mg daily
Max / 24h4 mg
PregnancyCategory C
Indications ▼
Moderate to severe rheumatoid arthritis in adults
COVID-19 associated severe inflammation (hospitalized adults)
Alopecia areata (investigational use)
Mechanism & Pharmacokinetics ▼
Mechanism: Selectively inhibits Janus kinase (JAK1 and JAK2), modulating cytokine signaling and reducing inflammation.
Pharmacokinetics: Oral absorption peak 1–2 hr; metabolized minimally in liver; excreted mainly via urine (~75%); half-life ~12.5 hr; once-daily dosing.
Dosage & Administration ▼
| Patient Category | Recommended Dose | Max / 24h |
|---|---|---|
| Adults (RA) | 2–4 mg once daily | 4 mg |
| COVID-19 (hospitalized) | 4 mg once daily, up to 14 days | 4 mg |
| Renal Impairment | Adjust per eGFR; moderate: 2 mg daily | 2 mg |
Side Effects ▼
Common: Upper respiratory infections, headache, nausea
Occasional: Increased liver enzymes, lipid elevations, diarrhea
Serious/Rare: Thrombosis, serious infections, cytopenias, malignancy risk
Contraindications ▼
Hypersensitivity to baricitinib
Active serious infections (TB, sepsis)
Severe hepatic impairment
Drug Interaction ▼
Strong CYP3A4 inducers: may reduce baricitinib levels
Other immunosuppressants: additive infection risk
Live vaccines: avoid during treatment
Pregnancy & Lactation ▼
Use only if benefits outweigh risks (Category C)
Excreted minimally in breast milk; caution advised
Clinical / Research Summary ▼
Rheumatoid Arthritis: Reduces joint inflammation, improves physical function and slows radiographic progression.
COVID-19: Shown to reduce recovery time and risk of progression to mechanical ventilation in hospitalized patients.
Long-term Safety: Clinical trials show infection risk, thrombosis risk; generally manageable with monitoring.
Pharmacokinetic Advantage: Oral once-daily dosing improves adherence.
Current Research: Expanded indications in autoimmune diseases, combination with biologics, long-term safety studies.
Storage & Handling ▼
Store at 20–25°C; protect from moisture & light
Keep out of reach of children
Patient Counseling Points ▼
How to take: Take once daily, with or without food.
Missed dose: Take as soon as possible; do not double dose.
Possible side effects: Respiratory infections, headache, nausea; monitor for severe infections or thrombosis.
Monitor: CBC, liver function, lipids, renal function as advised.
Drug interactions: Inform provider about immunosuppressants, vaccines, and CYP3A4 modulators.
Lifestyle advice: Avoid live vaccines; report signs of infection or unusual bruising.
Pregnancy and safety: Use only if clearly needed; breastfeeding with caution.
Brand Names (Bangladesh & Global) ▼
Bangladesh (Local Brands):
Global / International Brands:
Olumiant
Baricitinib
Olumiant
Medical Disclaimer: This clinical summary is for informational purposes only. Always follow guidance from a qualified healthcare professional for dosage, interactions, and use.
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