Aceclofenac
Rx
Generic NameAceclofenac
Therapeutic ClassNSAID
Clinical UsePain & Inflammation
Common Dose100 mg
PregnancyAvoid (especially 3rd trimester)
Indications ▼
Osteoarthritis
Rheumatoid arthritis
Ankylosing spondylitis
Musculoskeletal pain
Post-operative pain
Dental and traumatic pain
Mechanism & Pharmacokinetics ▼
Mechanism: Aceclofenac inhibits cyclooxygenase enzymes (COX-1 and COX-2), resulting in decreased prostaglandin synthesis, thereby reducing pain, inflammation, and swelling.
Pharmacokinetics: Rapidly absorbed after oral administration. Peak plasma concentration occurs within 1.25–3 hours. Highly protein bound. Metabolized in the liver mainly to diclofenac. Excreted primarily via urine.
Dosage & Administration ▼
| Patient Group | Dose | Frequency |
|---|---|---|
| Adults | 100 mg | Twice daily |
| Elderly | 100 mg | Once or twice daily (caution) |
| Maximum | 200 mg/day | Do not exceed |
Side Effects ▼
Dyspepsia
Nausea or vomiting
Abdominal pain
Diarrhea
Dizziness
Long-term use: GI bleeding, renal impairment
Contraindications ▼
History of hypersensitivity to NSAIDs
Active peptic ulcer or GI bleeding
Severe hepatic or renal impairment
Severe heart failure
Drug Interaction ▼
Increased bleeding risk with anticoagulants
Reduced antihypertensive effect of ACE inhibitors
Increased nephrotoxicity with diuretics
Avoid combination with other NSAIDs
Pregnancy & Lactation ▼
Contraindicated in third trimester
May cause premature closure of ductus arteriosus
Avoid during breastfeeding unless advised by physician
Clinical / Research Summary ▼
Therapeutic Role: Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) used for relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and musculoskeletal disorders.
Mechanism-Based Evidence: Aceclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, leading to reduced synthesis of prostaglandins, which decreases pain, inflammation, and fever.
Clinical Effectiveness: Clinical trials demonstrate significant improvement in pain, joint stiffness, and functional ability in patients with musculoskeletal disorders. It has a slightly better gastrointestinal tolerability compared to some other NSAIDs.
Safety Profile: Common adverse effects include gastrointestinal discomfort, nausea, dyspepsia, and mild headache. Rare but serious effects may include gastrointestinal bleeding, cardiovascular events, and renal impairment.
Research Directions: Studies continue to evaluate optimized dosing, combination therapy with gastroprotective agents, and long-term cardiovascular and renal safety.
Patient Counseling Points ▼
Administration: Take Aceclofenac orally with food or milk to reduce gastrointestinal irritation. Swallow tablets whole; do not crush or chew.
Missed Dose: Take as soon as remembered. If close to next dose, skip the missed dose. Do not double the dose.
Potential Side Effects: May include nausea, dyspepsia, abdominal pain, dizziness, or headache. Seek medical attention if severe gastrointestinal symptoms or allergic reactions occur.
Drug Interactions: Inform your doctor about use of anticoagulants, other NSAIDs, corticosteroids, antihypertensives, or nephrotoxic drugs.
Precautions: Avoid alcohol and smoking as they increase risk of stomach irritation. Use with caution in patients with hypertension, kidney, or liver disease.
Pregnancy & Lactation: Use only if clearly needed; avoid in the third trimester.
Follow-Up: Report persistent pain, gastrointestinal bleeding signs (black stools, vomiting blood), swelling, or shortness of breath immediately.
Storage & Handling ▼
Store below 30°C
Protect from light and moisture
Keep out of reach of children
Brand Names (Bangladesh & Global) ▼
Medical Disclaimer: This information is intended for educational purposes only and should not replace professional medical advice.
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