Sofosbuvir: Uses, Dosage, Side Effects & Brands | MedexInfo

Sofosbuvir

Rx

Generic NameSofosbuvir

Therapeutic ClassDirect-acting antiviral (DAA)

Common Strength400 mg tablet

PregnancyUse only if clearly needed

Indications ▼

Chronic hepatitis C virus (HCV) infection in adults and adolescents ≥12 years

Used in combination with other DAAs (e.g., Ledipasvir, Velpatasvir) for better efficacy

Effective for all HCV genotypes depending on combination therapy

Mechanism & Pharmacokinetics ▼

Mechanism: Nucleotide analog inhibitor of HCV NS5B RNA-dependent RNA polymerase. Incorporation into viral RNA leads to chain termination and inhibits viral replication.

Pharmacokinetics: Rapidly absorbed; peak plasma concentration in ~0.5–2 hours. Metabolized to active triphosphate GS-461203. Mainly eliminated via urine. Half-life of active metabolite ~27 hours.

Dosage & Administration ▼

Dosage should be determined based on combination therapy and genotype; always follow physician guidance.

Indication / Combination	Dose	Frequency / Notes
Chronic HCV (with Ledipasvir)	400 mg Sofosbuvir + 90 mg Ledipasvir	Once daily for 12 weeks (may vary by genotype and prior treatment)
Chronic HCV (with Velpatasvir)	400 mg Sofosbuvir + 100 mg Velpatasvir	Once daily for 12 weeks

Side Effects ▼

Fatigue, headache, nausea

Insomnia, dizziness

Anemia when combined with ribavirin

Rare hypersensitivity reactions

Contraindications ▼

Hypersensitivity to sofosbuvir or any excipient

Concomitant use with strong P-gp inducers (may reduce efficacy)

Drug Interaction ▼

Amiodarone: risk of symptomatic bradycardia

Strong P-gp inducers (rifampin, St. John’s Wort): reduce plasma levels

Co-administration with other DAAs is standard; monitor liver function

Pregnancy & Lactation ▼

Use only if clearly needed; consult physician

Excreted in breast milk unknown; weigh risk vs. benefit

Clinical / Research Summary ▼

Clinical Role: Key direct-acting antiviral for HCV; highly effective in combination therapy.

Advantage: Pan-genotypic activity, oral administration, high cure rates.

Limitation: Must be used in combination for most patients; expensive in some regions.

Monitoring: Liver function, HCV RNA viral load, renal function if comorbidities exist.

Patient Counseling Points ▼

Take exactly as prescribed, usually once daily

Do not skip doses; complete full course for viral clearance

Report unusual fatigue, jaundice, or severe nausea

Consult physician before starting any new medications

Storage & Handling ▼

Store below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Hopetavir 400 mg Buviren 400 mg G‑Sofosbuvir 400 mg Hepcee 400 mg HopSo 400 mg SB‑Sovir 400 mg Sofomax 400 mg Soforal 400 mg Sofovir‑C 400 mg Sofoxen 400 mg Sovalvir 400 mg Soventa 400 mg Suvirus 400 mg

Global:

Sovaldi®, Sofosbuvir®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Direct-acting antivirals (DAA) • Condition: Hepatitis C Virus (HCV) Infection