Salicylic Acid: Uses, Dosage, Side Effects & Brands | MedexInfo

Salicylic Acid

OTC

Generic NameSalicylic Acid

Therapeutic ClassKeratinolytic / Anti-acne

Common Strength0.5%–30% depending on formulation

Max / 24hUse as directed; avoid excessive application

PregnancyUse with caution; avoid high concentrations

Indications ▼

Acne vulgaris (comedonal and mild inflammatory)

Psoriasis (scaly plaques)

Seborrheic dermatitis

Removal of warts, corns, and calluses

Mechanism & Pharmacokinetics ▼

Mechanism: Salicylic acid is a keratolytic agent that softens and exfoliates the stratum corneum, reducing hyperkeratosis and promoting desquamation. It also has mild anti-inflammatory properties.

Pharmacokinetics: Minimal systemic absorption with topical use; metabolized to salicylates in small amounts. Excreted primarily in urine if systemically absorbed.

Dosage & Administration ▼

Indication	Formulation	Dose / Application
Acne	Gel or solution 0.5–2%	Apply thinly 1–2 times daily
Psoriasis	Ointment 3–6%	Apply to affected areas 1–2 times daily
Warts / Calluses	Solution or patch 17–30%	Apply once daily; cover with bandage if needed

Note: Avoid applying on broken skin or mucous membranes. Use lowest effective concentration for shortest duration.

Side Effects ▼

Local irritation, redness, burning sensation

Peeling or dryness of skin

Rare: allergic contact dermatitis

Excessive systemic absorption may lead to salicylate toxicity (rare, usually high concentration or large area)

Contraindications ▼

Hypersensitivity to salicylic acid or other salicylates

Open wounds or mucous membranes (relative)

Children under 2 years (risk of toxicity)

Drug Interaction ▼

Concurrent use of other topical salicylates: risk of additive irritation

Systemic salicylates (aspirin) may theoretically increase systemic exposure

Pregnancy & Lactation ▼

Use topical salicylic acid with caution; avoid high concentrations and large areas

Minimal absorption, generally safe in breastfeeding

Clinical / Research Summary ▼

Clinical Role: Widely used keratolytic for acne, psoriasis, seborrheic dermatitis, and removal of warts/calluses.

Advantage: Affordable, effective topical therapy; available OTC.

Limitation: Local irritation possible; not suitable for deep or widespread lesions at high concentration.

Monitoring: Skin tolerance; signs of local irritation; avoid systemic toxicity with excessive use.

Patient Counseling Points ▼

Apply a thin layer only to affected areas

Avoid contact with eyes, mouth, or mucous membranes

Discontinue if severe irritation occurs

Use sunscreen on treated areas if exposed to sunlight

Storage & Handling ▼

Store below 30°C

Protect from light and moisture

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Salicid® 12% Cream Salicare® 2% Cream Kerasol FCL 2% Lotion Keranil® 6% Cream Salidex® 6% Cream The Derma Co 2% Serum Salicylic Acid Gel Salicylic Acid Solution Salicylic Acid Lotion Salicylic Spot Treatment Gel

Global:

Clearasil® Duofilm®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Keratolytics • Condition: Acne • Condition: Psoriasis