Rosuvastatin: Uses, Dosage, Side Effects & Brands | MedexInfo

Rosuvastatin

Rx

Generic NameRosuvastatin

Therapeutic ClassHMG-CoA reductase inhibitor (statin)

Common Strength5, 10, 20, 40 mg tablets

PregnancyContraindicated

Indications ▼

Hypercholesterolemia: Treatment of high LDL cholesterol and total cholesterol in adults.

Mixed Dyslipidemia: Reduces elevated LDL, total cholesterol, ApoB, and triglycerides; increases HDL.

Cardiovascular Risk Reduction: Prevention of myocardial infarction, stroke, and other cardiovascular events in high-risk patients.

Mechanism & Pharmacokinetics ▼

Mechanism: Inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, decreasing hepatic cholesterol and upregulating LDL receptors.

Pharmacokinetics: Oral absorption ~20%; peak plasma 3–5 hours; 90% protein bound; metabolized minimally by CYP2C9; half-life ~19 hours; excreted mainly in feces.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults	10–20 mg orally once daily	40 mg
Elderly	Start with 5–10 mg orally once daily; adjust based on response	40 mg
Patients with Severe Renal Impairment	Start with 5 mg orally once daily; adjust carefully	20 mg

Note: Take at the same time each day, with or without food. Monitor liver function and CK levels periodically. Adjust dose based on efficacy and tolerance.

Side Effects ▼

Headache, dizziness

Myalgia, arthralgia

Abdominal pain, nausea

Rare: myopathy, rhabdomyolysis, elevated liver enzymes

Contraindications ▼

Pregnancy and lactation

Active liver disease or unexplained persistent elevated transaminases

Hypersensitivity to rosuvastatin

Drug Interaction ▼

CYP2C9 inhibitors (e.g., fluconazole) may increase levels

Fibrates: increased risk of myopathy/rhabdomyolysis

Antacids: may decrease absorption if taken simultaneously

Pregnancy & Lactation ▼

Contraindicated in pregnancy

Contraindicated during breastfeeding

Clinical / Research Summary ▼

Clinical Role: Effective statin for LDL reduction and cardiovascular risk management.

Advantage: Potent LDL-lowering, once-daily dosing, long half-life.

Limitation: Risk of myopathy, liver enzyme elevation; careful monitoring required.

Monitoring: Lipid profile, liver function tests, CK levels in high-risk patients.

Patient Counseling Points ▼

Take at the same time each day, with or without food

Report unexplained muscle pain, tenderness, or weakness

Avoid excessive alcohol

Follow up for periodic blood tests (liver, CK, lipid profile)

Storage & Handling ▼

Store at room temperature below 30°C

Protect from moisture and light

Keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Rolip® 5 mg Rolip® 10 mg Rolip® 20 mg Rosetor® 5 mg Rosetor® 10 mg Rosetor® 20 mg Rosuva® 5 mg Rosuva® 10 mg Rosuva® 20 mg Rosu® 5 mg Rosu® 10 mg Rosu® 20 mg Restat® 5 mg Restat® 10 mg Creston® 5 mg Creston® 10 mg Creston® 20 mg Rostab® 5 mg Rostab® 10 mg Rostab® 20 mg

Global:

Crestor®

Medical Disclaimer: For educational purposes only. Not a substitute for professional medical advice.

Reference Hubs:

• Drug Class: Statins • Condition: Hypercholesterolemia • Condition: Cardiovascular Risk Reduction