Phytomenadione (Injection): Uses, Dosage, Side Effects | MedexInfo

Phytomenadione (Injection)

Rx Only

Generic NamePhytomenadione

Therapeutic ClassVitamin K / Anticoagulant Antidote

Common Dose1–10 mg IV/IM as needed

Max / 24h10 mg (usually single dose)

PregnancyCategory C

Indications ▼

Prevention and treatment of hemorrhagic disease of the newborn

Treatment of hypoprothrombinemia due to vitamin K deficiency

Reversal of over-anticoagulation from warfarin or other vitamin K antagonists

Management of bleeding due to liver disease or malabsorption

Mechanism & Pharmacokinetics ▼

Mechanism: Acts as a cofactor for gamma-glutamyl carboxylase, enabling synthesis of clotting factors II, VII, IX, and X, as well as proteins C and S, restoring normal coagulation.

Pharmacokinetics: Rapidly absorbed and distributed after IM or IV injection. Metabolized in liver and excreted mainly via bile. Onset: IM 1–2 hours; IV 15–60 min. Duration: 12–24 hours.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults (Warfarin reversal)	2–10 mg IV slowly, depending on INR and bleeding severity	10 mg
Newborns (prophylaxis)	0.5–1 mg IM single dose at birth	1 mg
Children	0.1–0.3 mg/kg IM or IV depending on indication	10 mg
Elderly	Same as adult dosing; monitor coagulation parameters	10 mg

Note: Administer IV slowly (over several minutes) to avoid anaphylactoid reactions. IM preferred in newborns; avoid subcutaneous in thrombocytopenic patients.

Side Effects ▼

Common: Local pain at injection site, mild erythema

Occasional: Flushing, dizziness, transient hypotension

Rare: Anaphylactoid reactions, hypersensitivity, hyperbilirubinemia in neonates if IV high dose

Contraindications ▼

Hypersensitivity to phytomenadione or any component of the formulation

Severe anaphylactic reaction history to vitamin K injections

Drug Interaction ▼

Warfarin or other coumarin anticoagulants: may reduce anticoagulant effect

Bile acid sequestrants: may reduce absorption

Orlistat: may decrease vitamin K absorption

Pregnancy & Lactation ▼

Category C; use only if benefits outweigh risks

Excreted in breast milk; monitor infant for coagulation disturbances

Clinical / Research Summary ▼

Essential for preventing and treating vitamin K deficiency bleeding in neonates and adults.

Effective in rapid reversal of anticoagulation from vitamin K antagonists.

IV use should be slow to avoid severe hypersensitivity; IM preferred in prophylactic newborn doses.

Patient Counseling Points ▼

Inform patients about possible local injection pain or redness.

Report any signs of allergic reaction immediately.

Use only as prescribed; do not self-administer IV injections at home.

Storage & Handling ▼

Store at 2–8°C; protect from light

Do not freeze; keep out of reach of children

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Inj. K MM® 10 mg/ml Babykion® 2 mg/0.2 ml Dinakion® 10 mg/ml Dinakion MM® 2 mg/0.2 ml Inj. K MM® 2 mg/0.2 ml K‑One MM® 2 mg/0.2 ml Konakion® 2 mg/0.2 ml Konakion® 10 mg/ml Global:

Konakion® Vitamin K1 Injection (Generic)

Medical Disclaimer: This information is for educational purposes only and should not replace professional medical advice. Always consult a qualified healthcare provider.

Reference Hubs:

• Drug Class: Vitamins • Condition: Coagulation / Bleeding Disorders • Clinical Evidence & Trials

Phytomenadione (Injection): Uses, Dosage, Side Effects | MedexInfo Reviewed by Rasel Bapy on 15 May Rating: 5