Palonosetron: Uses, Dosage, Side Effects & Brands | MedexInfo

Palonosetron

Rx Only

Generic NamePalonosetron

Therapeutic Class5-HT3 Antagonist

Common Dose0.25 mg IV single dose

Max / 24h0.75 mg

PregnancyCategory B

Indications ▼

Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV)

Prevention of postoperative nausea and vomiting (PONV)

Radiation-induced nausea and vomiting (off-label)

Mechanism & Pharmacokinetics ▼

Mechanism: Selective serotonin (5-HT3) receptor antagonist that blocks serotonin receptors centrally (chemoreceptor trigger zone) and peripherally in the GI tract.

Pharmacokinetics: High receptor binding affinity and long half-life (~40 hours). Metabolized mainly by CYP2D6 (also CYP3A4 & CYP1A2). Eliminated via urine and feces.

Dosage & Administration ▼

Patient Category	Recommended Dose	Max / 24h
Adults (CINV)	0.25 mg IV single dose 30 minutes before chemotherapy	0.75 mg
Adults (PONV)	0.075 mg IV immediately before induction of anesthesia	0.075 mg
Oral (Combination therapy)	0.5 mg capsule prior to chemotherapy	0.5 mg
Elderly	No dose adjustment required	Same as adults

Note: Administer IV slowly over 30 seconds. Often combined with dexamethasone for enhanced antiemetic effect.

Side Effects ▼

Common: Headache, constipation

Occasional: Dizziness, fatigue

Rare: QT prolongation, hypersensitivity reactions

Contraindications ▼

Hypersensitivity to palonosetron or other 5-HT3 antagonists

Use cautiously in patients with cardiac conduction disorders

Drug Interaction ▼

Serotonergic drugs (SSRIs, SNRIs, tramadol): risk of serotonin syndrome

QT-prolonging agents: monitor ECG

CYP2D6 inhibitors: may increase levels

Pregnancy & Lactation ▼

Category B; no adequate human studies, use if clearly needed

Unknown if excreted in breast milk; caution advised

Clinical / Research Summary ▼

Superior control of delayed CINV compared to first-generation 5-HT3 antagonists.

Long half-life allows single-dose therapy per chemotherapy cycle.

Effective in combination with corticosteroids and NK1 receptor antagonists.

Well tolerated with minimal cardiac risk compared to older agents.

Patient Counseling Points ▼

Usually given before chemotherapy or surgery.

Report persistent constipation or severe headache.

Inform doctor about antidepressants or other serotonergic medicines.

Storage & Handling ▼

Store injection at 20–25°C

Protect from light

Do not freeze

Brand Names (Bangladesh & Global) ▼

Bangladesh:

Paloset® 0.5 mg Tablet Palanomed® 0.5 mg Tablet Palnox® 0.5 mg Tablet Palnox® 0.25 mg/5 ml Injection Palon® 0.5 mg Tablet Palorex® 0.5 mg Tablet Paloron® 0.5 mg Tablet Paloron® ODT 0.5 mg Palosis® 0.5 mg Tablet Paloxi® 0.5 mg Tablet Paloxi® ODT 0.5 mg Paloxiron® 0.5 mg Tablet Palzen® 0.5 mg Tablet Panoset® 0.5 mg Tablet Patron® 0.5 mg Tablet Vomiren® 0.5 mg Tablet

Global:

Aloxi® Palonosetron (Generic)

Medical Disclaimer: This information is for educational purposes only. Always consult a registered healthcare professional for medical advice.

Reference Hubs:

• Drug Class: Antiemetics • Condition: Chemotherapy-Induced Nausea • Clinical Evidence & Trials